Mohamed Shehab F, Helmi Feryal, El-Akiki Susanna, El Omri Halima, Nashwan Abdulqadir, Yassin Mohamed A
Hematology Department, National Center for Cancer Research (NCCCR), Hamad Medical Corporation (HMC), Doha, Qatar.
Department of Laboratory Medicine and Pathology, Hamad Medical Corporation (HMC), Doha, Qatar.
Case Rep Oncol. 2019 Dec 17;12(3):922-927. doi: 10.1159/000504929. eCollection 2019 Sep-Dec.
Hairy cell leukemia (HCL) is rare type of leukemia. This neoplasm is well-known to present with pancytopenia and splenomegaly. HCL is associated with BRAF mutation in 100% of cases. It is also associated with hematological and oncological malignancies such as melanoma and papillary thyroid cancer. Although the association of both cancers (HCL and papillary thyroid cancer) with BRAF mutation is well established in the literature, as far as we know it has not been reported before in the same patient. Here we report 48-year-old male diagnosed with HCL and papillary thyroid cancer and who is BRAF positive in both diagnostic tissues.
毛细胞白血病（HCL）是一种罕见的白血病类型。这种肿瘤以全血细胞减少和脾肿大为特征，广为人知。100%的毛细胞白血病病例与BRAF突变相关。它还与血液学和肿瘤学恶性肿瘤相关，如黑色素瘤和甲状腺乳头状癌。尽管两种癌症（毛细胞白血病和甲状腺乳头状癌）与BRAF突变的关联在文献中已有充分记载，但据我们所知，此前尚未有同一患者同时患这两种癌症的报道。在此，我们报告一名48岁男性，被诊断患有毛细胞白血病和甲状腺乳头状癌，且两种诊断组织均为BRAF阳性。
