Pepin Kay, Grimm Roger, Kargar Soudabeh, Howe B Matthew, Fritchie Karen, Frick Matthew, Wenger Doris, Okuno Scott, Ehman Richard, McGee Kiaran, James Sarah, Laack Nadia, Herman Michael, Pafundi Deanna
Department of Radiation Oncology, Mayo Clinic, 200 1 Street SW, Rochester, MN 55905.
Department of Radiology, Mayo Clinic, 200 1 Street SW, Rochester, MN 55905.
Biomed Phys Eng Express. 2019 Jul;5(4). doi: 10.1088/2057-1976/ab2175. Epub 2019 May 22.
Soft tissue sarcomas are a rare and heterogeneous group of malignancies that present significant diagnostic and therapeutic challenges. Patient stratification based on tumor aggressiveness and early therapeutic response based on quantitative imaging may improve prediction of treatment response and the evaluation of new treatment strategies in clinical trials. The purpose of this pilot study was to determine the technical feasibility of magnetic resonance elastography (MRE) and dynamic contrast-enhanced (DCE) MRI for the evaluation of sarcoma stiffness and perfusion in 9 patients with histologically confirmed sarcoma. Additionally, we assessed the feasibility of utilizing MRE and DCE-MRI for the early evaluation of response to radiation therapy in 4 patients to determine the utility of further evaluation in a larger cohort study. Tumor size, stiffness, and perfusion parameters all decreased from baseline at the time of the pre-surgery or follow-up MRI, and results were compared to pathology or conventional imaging. MRE and DCE-MRI may be useful for the quantitative evaluation of tumor stiffness and perfusion, and therapy response assessment in soft tissue sarcomas.
软组织肉瘤是一类罕见且异质性的恶性肿瘤，带来了重大的诊断和治疗挑战。基于肿瘤侵袭性进行患者分层，并基于定量成像进行早期治疗反应评估，可能会改善对治疗反应的预测以及在临床试验中对新治疗策略的评估。这项初步研究的目的是确定磁共振弹性成像（MRE）和动态对比增强（DCE）MRI评估9例组织学确诊肉瘤患者肉瘤硬度和灌注情况的技术可行性。此外，我们评估了利用MRE和DCE-MRI对4例患者放疗反应进行早期评估的可行性，以确定在更大规模队列研究中进一步评估的效用。在术前或随访MRI时，肿瘤大小、硬度和灌注参数均较基线水平下降，并将结果与病理或传统成像进行比较。MRE和DCE-MRI可能有助于软组织肉瘤肿瘤硬度和灌注的定量评估以及治疗反应评估。
