核仁组成区嗜银蛋白作为一种有效的诊断工具，用于确定不同类型牙源性囊肿的增殖特性。
AgNOR as an effective diagnostic tool for determining the proliferative nature of different types of odontogenic cysts.
作者信息
Tyagi Krishan Kumar, Chandra Lokesh, Kumar Manoj, Singh Sameep, Passi Deepak, Goyal Jyoti, Gupta Utkarsh
机构信息
Department of Oral and Maxillofacial Pathology, Kathmandu Medical College, Nepal.
Department of Oral and Maxillofacial Surgery, ESIC Dental College and Hospital, Rohini, Delhi, India.
出版信息
J Family Med Prim Care. 2020 Jan 28;9(1):125-130. doi: 10.4103/jfmpc.jfmpc_617_19. eCollection 2020 Jan.
OBJECTIVE
To determine the proliferative nature of different types of odontogenic cysts using silver-stained nucleolar organizer region (AgNOR) staining.
MATERIALS AND METHODS
Forty histopathological sections of each of odontogenic keratocyst, dentigerous, and radicular growth were taken into study. Two sections were produced using the paraffin block of separate cases, one was stained with hematoxylin and eosin and another segment was stained with silver nitrate method.
RESULTS
AgNOR staining shows black dots and other parts of nuclei show yellow-brown dots.
CONCLUSION
AgNOR, which stain for NOR-related proteins, corresponds to cell multiplication. Their amount regarding the number of AgNORs per cyst can be a good marker of the proliferative action of the cell in aggressive cystic lesion having malignant potential.
目的
使用银染核仁组织区（AgNOR）染色来确定不同类型牙源性囊肿的增殖特性。
材料与方法
选取牙源性角化囊肿、含牙囊肿和根尖囊肿各40个组织病理学切片进行研究。从不同病例的石蜡块制作两张切片，一张用苏木精和伊红染色，另一部分用硝酸银法染色。
结果
AgNOR染色显示黑点，细胞核的其他部分显示黄棕色点。
结论
AgNOR染色NOR相关蛋白，与细胞增殖相对应。它们在每个囊肿中AgNOR数量的多少可以作为具有恶性潜能的侵袭性囊性病变中细胞增殖作用的良好标志物。
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