牙源性囊肿和肿瘤中银染核仁组织区的分析
Analysis of silver stained nucleolar organizing regions in odontogenic cysts and tumors.
作者信息
Prasanna Md, Charan Cr, Reddy Ealla Kranti Kiran, Surekha V, Kulkarni Ganesh, Gokavarapu Sandhya
机构信息
Department of Oral and Maxillofacial Pathology, MNR Dental College, Sangareddy, Andhra Pradesh, India.
Department of Oral and Maxillofacial Pathology, Malla Reddy Dental College, Suraram, Jeedimetla, Hyderabad, Andhra Pradesh, India.
出版信息
J Oral Maxillofac Pathol. 2014 Sep;18(Suppl 1):S45-8. doi: 10.4103/0973-029X.141345.
OBJECTIVE
The present study aimed to investigate the probable differences in cell proliferation index of odontogenic cysts and tumors by means of a comparative silver stained nucleolar organizing region (AgNOR) quantification.
STUDY DESIGN
This descriptive cross-sectional study was done on archival paraffin blocks (n = 62), consisting of 10 odontogenic keratocysts, 10 dentigerous cysts, 10 radicular cysts, 10 conventional ameloblastomas, 10 adenomatoid odontogenic tumors, 10 calcifying epithelial odontogenic tumors and 2 ameloblasic carcinomas.
RESULTS
The mean AgNOR count of odontogenic cysts was 1.709 and the benign odontogenic tumors was 1.862. Highest AgNOR count was recorded in odontogenic keratocyst and lowest was seen in radicular cyst. Statistically significant difference in AgNOR counts of ameloblastoma and adenomatoid odontogenic tumor, amelobalastoma and calcifying epithelial odontogenic tumor, benign odontogenic tumors and ameloblastic carcinoma were seen. AgNORs in ameloblastic carcinoma were more in number and more widely spread.
CONCLUSION
AgNOR technique may be considered a good indicator of cell proliferation in odontogenic cysts and tumors.
目的
本研究旨在通过比较性银染核仁组织区（AgNOR）定量分析，探讨牙源性囊肿和肿瘤细胞增殖指数的可能差异。
研究设计
本描述性横断面研究对存档石蜡块（n = 62）进行，包括10例牙源性角化囊肿、10例含牙囊肿、10例根端囊肿、10例传统成釉细胞瘤、10例腺样牙源性肿瘤、10例钙化上皮性牙源性肿瘤和2例成釉细胞癌。
结果
牙源性囊肿的平均AgNOR计数为1.709，良性牙源性肿瘤为1.862。牙源性角化囊肿的AgNOR计数最高，根端囊肿最低。成釉细胞瘤与腺样牙源性肿瘤、成釉细胞瘤与钙化上皮性牙源性肿瘤、良性牙源性肿瘤与成釉细胞癌的AgNOR计数存在统计学显著差异。成釉细胞癌中的AgNOR数量更多且分布更广。
结论
AgNOR技术可被视为牙源性囊肿和肿瘤细胞增殖的良好指标。
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