Mobarki Abdullah A, Dobie Gasim, Saboor Muhammad, Madkhali Aymen M, Akhter Mohammad S, Hakamy Ali, Humran Adel, Hamali Yousof, Jackson Denise E, Hamali Hassan A
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Gizan, Saudi Arabia.
Medical Research Center, Jazan University, Gizan, Saudi Arabia.
Infect Drug Resist. 2021 Nov 23;14:4859-4864. doi: 10.2147/IDR.S342259. eCollection 2021.
The aims of the current study were to evaluate the importance of MPR and NLR as prognostic markers in ICU-admitted COVID-19 patients and to investigate the impact of COVID-19 on hematological and coagulation parameters in patients from Jazan region of Saudi Arabia.
This retrospective study was conducted between October 2020 and January 2021 at King Fahad Central Hospital, Jazan region. Medical files, which included the results of complete blood count (CBC), calculated mean platelet volume to platelet count ratio (MPR) and neutrophils-to-lymphocytes ratio (NLR) parameters, coagulation profile and D-dimer test, of 96 (64 male and 32 female) COVID-19-infected patients admitted to the intensive care unit were reviewed. Associations between the test results and COVID-19 infection outcomes (discharged [DC] or passed away [PA]) were measured.
The results of the current study demonstrate overall significant differences in CBC parameters between PA group as compared to DC group (P < 0.05). The PA group had a significantly elevated MPR (10.15±12.16 vs 4.04±1.5; P < 0.01) and NLR (18.29±19.82 vs 7.35±9.68; P < 0.01) as compared to the DC group, suggesting an association between these parameters and mortality. Odds ratios analysis also showed that adjustment for demographic variables and comorbidities did not weaken the observed association.
Elevated MPR and NLR are associated with poor prognosis in COVID-19 patients and could be useful as therapy management indicators.
本研究旨在评估平均血小板体积与血小板计数比值（MPR）和中性粒细胞与淋巴细胞比值（NLR）作为入住重症监护病房（ICU）的新型冠状病毒肺炎（COVID-19）患者预后标志物的重要性，并调查COVID-19对沙特阿拉伯吉赞地区患者血液学和凝血参数的影响。
本回顾性研究于2020年10月至2021年1月在吉赞地区法赫德国王中央医院进行。对96例（64例男性和32例女性）入住重症监护病房的COVID-19感染患者的病历进行了回顾，病历包括全血细胞计数（CBC）结果、计算得出的平均血小板体积与血小板计数比值（MPR）和中性粒细胞与淋巴细胞比值（NLR）参数、凝血指标和D-二聚体检测结果。测量了检测结果与COVID-19感染结局（出院[DC]或死亡[PA]）之间的关联。
本研究结果表明，与出院组相比，死亡组的CBC参数总体存在显著差异（P<0.05）。与出院组相比，死亡组的MPR（10.15±12.16对4.04±1.5；P<0.01）和NLR（18.29±19.82对7.35±9.68；P<0.01）显著升高，表明这些参数与死亡率之间存在关联。比值比分析还表明，对人口统计学变量和合并症进行调整并未削弱观察到的关联。
MPR和NLR升高与COVID-19患者的不良预后相关，可作为治疗管理指标。
