Aaptolines A 和 B，两种来自海洋海绵 Aaptos aaptos 的新喹啉生物碱。

Aaptolines A and B, Two New Quinoline Alkaloids from the Marine Sponge Aaptos aaptos.

机构信息

College of Biological and Environmental Engineering, Changsha University, Changsha, 410022, P. R. China.

Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.

出版信息

Chem Biodivers. 2020 Apr;17(4):e2000074. doi: 10.1002/cbdv.202000074. Epub 2020 Mar 23.

DOI:10.1002/cbdv.202000074

PMID:32110847

Abstract

Two new quinoline alkaloids, aaptolines A and B, were isolated from the marine sponge Aaptos aaptos. Their structures were determined by HR-ESI-MS data, NMR analysis, and X-ray crystallography. Structurally, aaptoline A is characterized as having a quinoline skeleton fused with a 1,4-dioxane motif at the C(7)-C(8) position, whereas aaptoline B possessed an intriguing 1H-pyrrolo[2,3-g]quinoline moiety. The cytotoxic assay of these compounds showed no cytotoxicity towards HepG2, A549, and PC9 cancer cell lines and had IC values greater than 20 μm.

摘要

从海洋海绵 Aaptos aaptos 中分离得到两个新的喹啉生物碱，aaptolines A 和 B。通过高分辨电喷雾质谱（HR-ESI-MS）数据、NMR 分析和 X 射线晶体学确定了它们的结构。结构上，aaptoline A 的特征在于喹啉骨架在 C(7)-C(8) 位置与 1,4-二恶烷基融合，而 aaptoline B 则具有引人注目的 1H-吡咯并[2,3-g]喹啉部分。这些化合物的细胞毒性测定表明，它们对 HepG2、A549 和 PC9 癌细胞系没有细胞毒性，IC 值大于 20μm。