Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
Org Lett. 2012 Apr 20;14(8):1994-7. doi: 10.1021/ol3004589. Epub 2012 Apr 3.
Suberitine A-D (1-4), four new bis-aaptamine alkaloids with two aaptamine skeleton units, 8,9,9-trimethoxy-9H-benzo[de][1,6]-naphthyridine and demethyl(oxy)-aaptamine, linked through a rare C-3-C-3' or C-3-C-6' σ-bond between the 1,6-naphthyridine rings, together with two known monomers 5 and 6, were isolated from the marine sponge Aaptos suberitoides. Their structures were elucidated using NMR spectroscopy. Compounds 2 and 4 showed potent cytotoxicity against P388 cell lines, with IC(50) values of 1.8 and 3.5 μM, respectively.
苏比丁 A-D（1-4），四个新的双阿朴菲生物碱，具有两个阿朴菲骨架单元，8,9,9-三甲氧基-9H-苯并[de][1,6]-萘啶和去甲氧基-阿朴菲，通过 1,6-萘啶环之间罕见的 C-3-C-3' 或 C-3-C-6'σ-键连接，以及两个已知单体 5 和 6，从海洋海绵 Aaptos suberitoides 中分离得到。它们的结构通过 NMR 光谱阐明。化合物 2 和 4 对 P388 细胞系表现出强烈的细胞毒性，IC50 值分别为 1.8 和 3.5 μM。
