Department of Food Science and Human Nutrition, Jeonbuk National University and Obesity Research Center, Jeonju 54896, Jeonbuk, Korea.
Department of Food and Biotechnology, Woosuk University, Samnye-eup, Wanju-gun 55338, Jeonbuk, Korea.
Nutrients. 2020 Feb 26;12(3):604. doi: 10.3390/nu12030604.
Our previous study reported that lactic acid bacteria ( OPK-3) isolated from kimchi ameliorated intracellular lipid accumulation in 3T3-L1 adipocyte. The current study explored potential roles of OPK-3 (KLAB) on preventing body weight gain and its effect on the inflammatory response of adipose tissue. Male C57BL/6 mice ( = 10) were divided into four groups: normal diet with distilled water (NDC), high-fat diet with distilled water (HDC), high-fat diet with L-ornithine (OTC) or high-fat diet with KLAB. The KLAB supplement resulted in significantly lower body weight, lower epididymal fat tissue mass, and lower serum and hepatic TG levels than the HDC. KLAB supplementation improved serum cytokines, and real-time polymerase chain reaction (PCR) analysis showed significantly lower inflammatory cytokine mRNA levels in epididymal adipose tissue. These results suggest that the administration of KLAB inhibits the induction of inflammation in adipose tissue along with the inhibition of weight gain. Therefore, this study demonstrates the therapeutic and beneficial value of this strain produced during the fermentation of kimchi.
我们之前的研究报告称，从泡菜中分离出的乳酸菌（OPK-3）可改善 3T3-L1 脂肪细胞内的脂质积累。本研究探讨了 OPK-3（KLAB）在预防体重增加及其对脂肪组织炎症反应的潜在作用。雄性 C57BL/6 小鼠（ = 10）分为四组：用蒸馏水喂养的正常饮食（NDC）、用蒸馏水喂养的高脂肪饮食（HDC）、用 L-鸟氨酸喂养的高脂肪饮食（OTC）或用 KLAB 喂养的高脂肪饮食。与 HDC 相比，KLAB 补充剂可显著降低体重、附睾脂肪组织质量和血清及肝 TG 水平。KLAB 补充剂可改善血清细胞因子，实时聚合酶链反应（PCR）分析显示附睾脂肪组织中促炎细胞因子 mRNA 水平显著降低。这些结果表明，KLAB 的给药可抑制脂肪组织炎症的诱导，同时抑制体重增加。因此，本研究证明了这种在泡菜发酵过程中产生的菌株的治疗和有益价值。
