Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-9001, USA.
Science. 2013 Jan 11;339(6116):172-7. doi: 10.1126/science.1230721.
Metabolism and immunity are inextricably linked both to each other and to organism-wide function, allowing mammals to adapt to changes in their internal and external environments. In the modern context of obesogenic diets and lifestyles, however, these adaptive responses can have deleterious consequences. In this Review, we discuss the pleiotropic actions of inflammation and insulin resistance in metabolic homeostasis and disease. An appreciation of the adaptive context in which these responses arose is useful for understanding their pathogenic actions in disease.
新陈代谢和免疫相互关联，也与全身功能相关，使哺乳动物能够适应其内部和外部环境的变化。然而，在现代肥胖症饮食和生活方式的背景下，这些适应性反应可能会产生有害的后果。在这篇综述中，我们讨论了炎症和胰岛素抵抗在代谢稳态和疾病中的多效作用。了解这些反应产生的适应性背景有助于理解它们在疾病中的致病作用。
