Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran; Epidemiology and Biostatistics Unit, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.
Pathol Res Pract. 2020 Apr;216(4):152855. doi: 10.1016/j.prp.2020.152855. Epub 2020 Feb 13.
The associations between viruses and the cancer have been conducted in several studies while there has been no systematic review and meta-analysis about the association between viral infections and thyroid cancer (TC). Therefore, we investigated the association between viral infection and TC risk.
Systematic search was done from 1994 to 2019 in Web of sciences (ISI), PubMed, and Scopus databases. Pooled logarithm of odds ratio (OR) and their corresponding 95 % confidence interval (CI) and pooled prevalence of viral infections were calculated to find the association between the viral infections and TC risk and overall prevalence of the viral infections in TC.
Twenty-three of 852 original articles were selected and included in the study. According to the results of the random effect meta-analysis, the pooled prevalence of viral infections in the TC patients was 37 % (95 % C. I = 22 %-55 %). In addition, there was a significant association between viral infections (log (OR) = 1.51, 95 % credible interval = 0.68-2.39) and TC risk. The highest associations were observed between TC risk and Simian Vacuolating Virus 40 (SV40) and B19 infections, respectively. The lowest non-significant association was found between TC risk and Poliovirus type 1 infection. The significantly heterogeneity was observed between included studies (Q test: p-value<0.001; I = 73.82 %; τ = 1.08, 95 % Cr. I = 0.47-1.94).
Results clearly demonstrated the potential pathogenetic association between viral infections and increased risk of TC.
已有多项研究探讨了病毒与癌症之间的关联，但尚未有系统评价和荟萃分析研究病毒感染与甲状腺癌（TC）之间的关联。因此，我们调查了病毒感染与 TC 风险之间的关联。
从 1994 年至 2019 年，我们在 Web of Sciences（ISI）、PubMed 和 Scopus 数据库中进行了系统检索。计算汇总对数优势比（OR）及其 95%置信区间（CI）和病毒感染的汇总患病率，以发现病毒感染与 TC 风险之间的关联，以及 TC 中病毒感染的总体患病率。
从 852 篇原始文章中筛选出 23 篇，并纳入本研究。根据随机效应荟萃分析的结果，TC 患者的病毒感染总患病率为 37%（95%置信区间为 22%-55%）。此外，病毒感染与 TC 风险之间存在显著关联（log（OR）=1.51，95%可信区间=0.68-2.39）。与 TC 风险相关性最高的分别是猿猴空泡病毒 40（SV40）和 B19 感染，而与 1 型脊髓灰质炎病毒感染的相关性最低，且无统计学意义。纳入研究之间存在显著异质性（Q 检验：p 值<0.001；I=73.82%；τ=1.08，95%置信区间=0.47-1.94）。
研究结果明确表明病毒感染与 TC 风险增加之间存在潜在的致病关联。
