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失眠、催眠药物使用与道路碰撞:基于人群的 5 年队列研究。

Insomnia, hypnotic use, and road collisions: a population-based, 5-year cohort study.

机构信息

École de psychologie, Université Laval, Québec, Canada.

Centre d'étude des troubles du sommeil, Institut universitaire en santé mentale de Québec, Québec, Canada.

出版信息

Sleep. 2020 Aug 12;43(8). doi: 10.1093/sleep/zsaa032.

Abstract

STUDY OBJECTIVES

The study objectives were to examine accidental risks associated with insomnia or hypnotic medications, and how these risk factors interact with sex and age.

METHODS

A population-based sample of 3,413 adults (Mage = 49.0 years old; 61.5% female), with or without insomnia, were surveyed annually for five consecutive years about their sleep patterns, sleep medication usage, and road collisions.

RESULTS

There was a significant risk of reporting road collisions associated with insomnia (hazard ratio [HR] = 1.20; 95% confidence interval [CI] = 1.00-1.45) and daytime fatigue (HR = 1.21; 95% CI = 1.01-1.47). Insomnia and its daytime consequences were perceived to have played some contributory role in 40% of the reported collisions. Both chronic (HR = 1.50; 95% CI = 1.17-1.91) and regular use of sleep medications (HR = 1.58; 95% CI = 1.16-2.14) were associated with higher accidental risks, as well as being young female with insomnia and reporting excessive daytime sleepiness.

CONCLUSIONS

Both insomnia and use of sleep medications are associated with significant risks of road collisions, possibly because of or in association with some of their residual daytime consequences (i.e. fatigue and poor concentration). The findings also highlight a new group of at-risk patients, i.e. young women reporting insomnia and excessive daytime sleepiness.

摘要

研究目的

本研究旨在考察与失眠或催眠药物相关的意外风险,以及这些风险因素如何与性别和年龄相互作用。

方法

本研究采用基于人群的样本,共纳入 3413 名成年人(平均年龄为 49.0 岁,61.5%为女性),这些成年人或患有失眠,或不患有失眠。在接下来的五年中,每年对他们的睡眠模式、睡眠药物使用情况和道路碰撞情况进行调查。

结果

与失眠(风险比 [HR] = 1.20;95%置信区间 [CI] = 1.00-1.45)和白天疲劳(HR = 1.21;95% CI = 1.01-1.47)相关,报告道路碰撞的风险显著增加。失眠及其白天后果被认为在 40%的报告碰撞中起了一定的作用。慢性(HR = 1.50;95% CI = 1.17-1.91)和常规使用睡眠药物(HR = 1.58;95% CI = 1.16-2.14)均与更高的意外风险相关,此外,年轻的女性失眠患者且报告白天过度嗜睡也与更高的意外风险相关。

结论

失眠和使用睡眠药物都与道路碰撞的显著风险相关,这可能是由于或与它们残留的白天后果(即疲劳和注意力不集中)有关。这些发现还突出了一个新的高风险患者群体,即报告失眠和白天过度嗜睡的年轻女性。

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