Centro de Referencia para Lactobacilos (CERELA-CONICET), Chacabuco 145, T4000ILC, San Miguel de Tucumán, Tucumán, Argentina.
Cátedra de Microbiología Superior, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, San Miguel de Tucumán, Tucumán, Argentina.
Appl Microbiol Biotechnol. 2020 Apr;104(8):3331-3337. doi: 10.1007/s00253-020-10487-1. Epub 2020 Feb 28.
Recent studies have shown that inflammatory diseases are becoming more frequent throughout the world. The causes of these disorders are multifactorial and include genetic, immunological, and environmental factors, and intestinal microbiota dysbiosis. The use of beneficial microorganisms has shown to be useful in the prevention and treatment of disorders such as colitis, mucositis, and even colon cancer by their immune-stimulating properties. It has also been shown that certain vitamins, especially riboflavin and folate derivatives, have proven to be helpful in the treatment of these diseases. The application of vitamin-producing lactic acid bacteria, especially strains that produce folate and riboflavin together with immune-stimulating strains, could be used as adjunct treatments in patients suffering from a wide range of inflammatory diseases since they could improve treatment efficiency and prevent undesirable side effects in addition to their nutrition values. In this review, the most up to date information on the current knowledge and uses of vitamin-producing lactic acid bacteria is discussed in order to stimulate further studies in this field.
最近的研究表明，炎症性疾病在全球范围内变得越来越普遍。这些疾病的原因是多因素的，包括遗传、免疫和环境因素以及肠道微生物失调。有益微生物的使用已被证明可通过其免疫刺激特性在预防和治疗结肠炎、黏膜炎甚至结肠癌等疾病方面发挥作用。还表明，某些维生素，特别是核黄素和叶酸衍生物，已被证明对这些疾病的治疗有帮助。应用产维生素的乳酸菌，特别是同时产生叶酸和核黄素的免疫刺激菌株的应用，可以作为患有各种炎症性疾病的患者的辅助治疗方法，因为它们除了具有营养价值外，还可以提高治疗效率并预防不良的副作用。在这篇综述中，讨论了产维生素乳酸菌的最新知识和用途，以激发该领域的进一步研究。
