Department of Physical Education, College of Education, Daegu Catholic University, Gyeongsan, Republic of Korea.
Center for Vascular Research, Institute for Basic Science (IBS), Daejeon, Republic of Korea.
PLoS One. 2019 Feb 28;14(2):e0210854. doi: 10.1371/journal.pone.0210854. eCollection 2019.
Recent studies have demonstrated the immunomodulatory effects of heat-killed lactic acid bacteria. The aim of this study was to evaluate the protective effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on a model of inflammatory bowel disease (IBD). A total of 28 female NC/Nga mice were divided into 4 treatment groups. Controls were fed a normal commercial diet. In the experimental groups, colitis was induced by rectal administration of dinitrobenzene sulfonic acid. Two groups were orally administered 2 and 17 mg/kg EF-2001, respectively. EF-2001 treatment decreased the expression of several cytokines, including cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), interferon (IFN)-γ, interleukin (IL)-1β, and IL-6 in inflamed colon compared to the DNBS alone group. In addition, EF-2001 suppressed DNBS-induced colonic tissue destruction. Therefore, this study strongly suggests that EF-2001 could alleviate the inflammation associated with mouse IBD.
最近的研究表明，热灭活乳酸菌具有免疫调节作用。本研究旨在评估粪肠球菌 EF-2001（EF-2001）对炎症性肠病（IBD）模型的保护作用。将 28 只雌性 NC/Nga 小鼠分为 4 个治疗组。对照组喂食正常商业饮食。在实验组中，通过直肠给予二硝基苯磺酸诱导结肠炎。两组分别口服 2 和 17mg/kg 的 EF-2001。与单独给予 DNBS 组相比，EF-2001 治疗降低了炎症结肠中几种细胞因子的表达，包括环加氧酶（COX）-2、诱导型一氧化氮合酶（iNOS）、干扰素（IFN）-γ、白细胞介素（IL）-1β 和 IL-6。此外，EF-2001 抑制了 DNBS 诱导的结肠组织破坏。因此，本研究强烈表明 EF-2001 可减轻与小鼠 IBD 相关的炎症。
