de Moreno de LeBlanc Alejandra, Levit Romina, de Giori Graciela Savoy, LeBlanc Jean Guy
Centro de Referencia para Lactobacilos (CERELA-CONICET). Chacabuco 145, (T4000ILC) San Miguel de Tucuman, Tucuman, Argentina.
Cátedra de Microbiología Superior, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, San Miguel de Tucumán, Tucumán, Argentina CERELA-CONICET, San Miguel de Tucumán, Tucumán, C.P. 4000, Argentina.
Antiinflamm Antiallergy Agents Med Chem. 2018;17(1):50-56. doi: 10.2174/1871523017666180502170659.
Current therapies for against inflammatory bowel disease (IBD) are sometimes limited by high costs, high toxicities and/or undesirable side effects, reasons for which new treatments are constantly being developed and studied. In this regards, an increasing mass of data has demonstrated that fecal transplantations and probiotic supplementations have shown promising effects and could be considered as adjunct IBD treatments to decrease some of the unwanted side effects caused by primary treatments. Furthermore, there is also mounting evidence that suggests that certain vitamins could provide antiinflammatory effects and it has been shown that certain strains of lactic acid bacteria (LAB), the most commonly used probiotic microorganisms, can produce biologically active forms of certain vitamins.
To discuss the potential role of the vitamin-producing LAB on intestinal inflammatory diseases.
A thorough search of bibliographic databases for peer-reviewed research on the effect of vitamins produced by LAB on inflammatory processes was performed.
There is mounting research that vitamin producing LAB could provide antiinflammatory effects.
The potential role of vitamin producing LAB was discussed not only because they could be used to decrease inflammation but also because they could provide the host with essential nutrients that are normally deficient in IBD patients due to altered intestinal morphologies.
目前针对炎症性肠病（IBD）的治疗方法有时会受到高成本、高毒性和/或不良副作用的限制，因此不断有新的治疗方法被研发和研究。在这方面，越来越多的数据表明，粪便移植和益生菌补充已显示出有前景的效果，可被视为IBD的辅助治疗方法，以减少一些主要治疗引起的不良副作用。此外，也有越来越多的证据表明某些维生素可能具有抗炎作用，并且已经表明某些乳酸菌（LAB）菌株，即最常用的益生菌微生物，可以产生某些维生素的生物活性形式。
探讨产维生素乳酸菌在肠道炎症性疾病中的潜在作用。
全面检索文献数据库，查找关于LAB产生的维生素对炎症过程影响的同行评审研究。
越来越多的研究表明产维生素乳酸菌可提供抗炎作用。
讨论了产维生素乳酸菌的潜在作用，不仅因为它们可用于减轻炎症，还因为它们可为宿主提供因肠道形态改变而在IBD患者中通常缺乏的必需营养素。
