Kohzadi Mozhgan, Khazaei Mohammad Rasool, Choobsaz Farzaneh, Khazaei Mozafar
Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Int J Fertil Steril. 2020 Apr;14(1):27-33. doi: 10.22074/ijfs.2020.5809. Epub 2020 Feb 25.
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Anti-Mullerian hormone (AMH) is a valid indicator of ovarian function and is used for PCOS diagnosis. Some studies have shown that adipokines affect the synthesis of AMH, and therefore they are somehow related in function. The aim of the present study was to determine the relationship between serum levels of AMH, adiponectin and oxidative stress markers in PCOS patients.
In this cross-sectional study, PCOS patients and healthy women (80 cases in total) were investigated. Serum levels of AMH, adiponectin, gonadotropins, androgens, total antioxidant capacity (TAC), nitric oxide (NO) and insulin resistance (IR) were measured by standard methods. An independent t test was used to compare the two groups and Pearson correlation coefficient was used to determine the relationship between variables.
There was a significant difference between the means of AMH (5.16 ± 5.3 vs. 2.44 ± 2.5 ng/mL) (P=0.007) and adiponectin (24.55 ± 9.41 vs. 30.57 ± 14.2 μg/L) (P=0.029) among the PCOS and control groups, respectively. The correlation between AMH and adiponectin in the control group was statistically significant and negative (P=0.028, r=-0.35), while in the PCOS group it was not significant (P=0.11, r=-0.25).
Various biochemical and hormonal factors differ between PCOS and healthy women. Different factors can influence AMH and adiponectin levels independently of PCOS in women of reproductive age.
多囊卵巢综合征（PCOS）是育龄女性最常见的内分泌紊乱疾病。抗苗勒管激素（AMH）是卵巢功能的有效指标，用于PCOS的诊断。一些研究表明，脂肪因子会影响AMH的合成，因此它们在功能上存在一定关联。本研究的目的是确定PCOS患者血清中AMH、脂联素和氧化应激标志物之间的关系。
在这项横断面研究中，对PCOS患者和健康女性（共80例）进行了调查。采用标准方法测量血清中AMH、脂联素、促性腺激素、雄激素、总抗氧化能力（TAC）、一氧化氮（NO）和胰岛素抵抗（IR）水平。采用独立t检验比较两组，采用Pearson相关系数确定变量之间的关系。
PCOS组和对照组的AMH均值（5.16±5.3 vs. 2.44±2.5 ng/mL）（P=0.007）和脂联素均值（24.55±9.41 vs. 30.57±14.2 μg/L）（P=0.029）分别存在显著差异。对照组中AMH与脂联素之间的相关性具有统计学意义且呈负相关（P=0.028，r=-0.35），而在PCOS组中则不显著（P=0.11，r=-0.25）。
PCOS患者与健康女性之间存在多种生化和激素因素差异。不同因素可独立于PCOS影响育龄女性的AMH和脂联素水平。
