Common fibrin deposition and tissue plasminogen activator downregulation in nasal polyps with distinct inflammatory endotypes.
作者信息
Chen Cai-Ling, Yao Yin, Pan Li, Hu Si-Tao, Ma Jin, Wang Zhi-Chao, Kern Robert C, Schleimer Robert P, Liu Zheng
机构信息
Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Deprtment of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
出版信息
J Allergy Clin Immunol. 2020 Sep;146(3):677-681. doi: 10.1016/j.jaci.2020.02.010. Epub 2020 Feb 26.
Abstract
摘要
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Common fibrin deposition and tissue plasminogen activator downregulation in nasal polyps with distinct inflammatory endotypes.具有不同炎症亚型的鼻息肉中常见的纤维蛋白沉积和组织纤溶酶原激活物下调。
J Allergy Clin Immunol. 2020 Sep;146(3):677-681. doi: 10.1016/j.jaci.2020.02.010. Epub 2020 Feb 26.
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本文引用的文献
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Increased thrombin-activatable fibrinolysis inhibitor levels in patients with chronic rhinosinusitis with nasal polyps.慢性鼻-鼻窦炎伴鼻息肉患者中凝血酶激活的纤溶抑制物水平升高。
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Nattokinase, profibrinolytic enzyme, effectively shrinks the nasal polyp tissue and decreases viscosity of mucus.纳豆激酶，纤维蛋白溶解酶，能有效缩小鼻息肉组织并降低黏液的粘性。
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Heterogeneous inflammatory patterns in chronic rhinosinusitis without nasal polyps in Chicago, Illinois.伊利诺伊州芝加哥市非鼻息肉慢性鼻-鼻窦炎的异质性炎症模式。
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Features of airway remodeling in different types of Chinese chronic rhinosinusitis are associated with inflammation patterns.不同类型中国慢性鼻-鼻窦炎的气道重塑特征与炎症模式相关。
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Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression.纤维蛋白溶解功能障碍导致组织型纤溶酶原激活物表达减少引起鼻息肉中纤维蛋白过度沉积。
Am J Respir Crit Care Med. 2013 Jan 1;187(1):49-57. doi: 10.1164/rccm.201207-1292OC. Epub 2012 Nov 15.
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Role of thrombin in chronic rhinosinusitis-associated tissue remodeling.凝血酶在慢性鼻-鼻窦炎相关组织重塑中的作用。
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