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1
Common fibrin deposition and tissue plasminogen activator downregulation in nasal polyps with distinct inflammatory endotypes.具有不同炎症亚型的鼻息肉中常见的纤维蛋白沉积和组织纤溶酶原激活物下调。
J Allergy Clin Immunol. 2020 Sep;146(3):677-681. doi: 10.1016/j.jaci.2020.02.010. Epub 2020 Feb 26.
2
Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression.纤维蛋白溶解功能障碍导致组织型纤溶酶原激活物表达减少引起鼻息肉中纤维蛋白过度沉积。
Am J Respir Crit Care Med. 2013 Jan 1;187(1):49-57. doi: 10.1164/rccm.201207-1292OC. Epub 2012 Nov 15.
3
Formation of nasal polyps: The roles of innate type 2 inflammation and deposition of fibrin.鼻息肉的形成：固有 2 型炎症和纤维蛋白沉积的作用。
J Allergy Clin Immunol. 2020 Mar;145(3):740-750. doi: 10.1016/j.jaci.2020.01.027.
4
Increased expression of factor XIII-A in patients with chronic rhinosinusitis with nasal polyps.慢性鼻-鼻窦炎伴鼻息肉患者中因子 XIII-A 的表达增加。
J Allergy Clin Immunol. 2013 Sep;132(3):584-592.e4. doi: 10.1016/j.jaci.2013.02.003. Epub 2013 Mar 28.
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Transcription Factor Specificity Protein 1 Regulates Inflammation and Fibrin Deposition in Nasal Polyps Via the Regulation of microRNA-125b and the Wnt/β-catenin Signaling Pathway.转录因子特异性蛋白 1 通过调节 microRNA-125b 和 Wnt/β-catenin 信号通路调节鼻息肉中的炎症和纤维蛋白沉积。
Inflammation. 2022 Jun;45(3):1118-1132. doi: 10.1007/s10753-021-01605-w. Epub 2022 Jan 6.
6
[Plasminogen activation by tissue plasminogen activator on fibrin clots with different surface structures].[组织型纤溶酶原激活剂在具有不同表面结构的纤维蛋白凝块上激活纤溶酶原]
Ukr Biokhim Zh (1999). 2001 May-Jun;73(3):87-90.
7
Lipoprotein(a), fibrin binding, and plasminogen activation.脂蛋白(a)、纤维蛋白结合与纤溶酶原激活
Arteriosclerosis. 1990 Mar-Apr;10(2):240-5. doi: 10.1161/01.atv.10.2.240.
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What drives "fibrinolysis"?是什么驱动了“纤维蛋白溶解”？
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Plasminogen activators in human nasal polyps and mucosa.人鼻息肉和鼻黏膜中的纤溶酶原激活剂
Rhinology. 1997 Dec;35(4):175-7.
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The interaction of streptokinase.plasminogen activator complex, tissue-type plasminogen activator, urokinase and their acylated derivatives with fibrin and cyanogen bromide digest of fibrinogen. Relationship to fibrinolytic potency in vitro.链激酶 - 纤溶酶原激活物复合物、组织型纤溶酶原激活物、尿激酶及其酰化衍生物与纤维蛋白及纤维蛋白原溴化氰消化产物的相互作用。与体外纤溶活性的关系。
Biochem J. 1987 Oct 15;247(2):395-400. doi: 10.1042/bj2470395.

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The immunology of asthma and chronic rhinosinusitis.哮喘与慢性鼻-鼻窦炎的免疫学
Nat Rev Immunol. 2025 Apr 16. doi: 10.1038/s41577-025-01159-0.
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Type 2 immunity in allergic diseases.过敏性疾病中的2型免疫。
Cell Mol Immunol. 2025 Mar;22(3):211-242. doi: 10.1038/s41423-025-01261-2. Epub 2025 Feb 17.
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Serum Proteomic Analysis Revealed Biomarkers for Eosinophilic Chronic Rhinosinusitis with Nasal Polyps Pathophysiology.血清蛋白质组学分析揭示了嗜酸性粒细胞性慢性鼻-鼻窦炎伴鼻息肉病理生理学的生物标志物。
J Inflamm Res. 2024 Feb 7;17:805-821. doi: 10.2147/JIR.S444280. eCollection 2024.
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Endotypic heterogeneity and pathogenesis in chronic rhinosinusitis.慢性鼻-鼻窦炎的表型异质性和发病机制。
Curr Opin Allergy Clin Immunol. 2024 Feb 1;24(1):1-8. doi: 10.1097/ACI.0000000000000954. Epub 2023 Nov 15.
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Development of Adaptive Immunity and Its Role in Lung Remodeling.适应性免疫的发展及其在肺重塑中的作用。
Adv Exp Med Biol. 2023;1426:287-351. doi: 10.1007/978-3-031-32259-4_14.
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Identification of Inflammatory Endotypes by Clinical Characteristics and Nasal Secretion Biomarkers in Chronic Rhinosinusitis with Nasal Polyps.基于临床特征和鼻腔分泌物生物标志物对慢性鼻-鼻窦炎伴鼻息肉患者进行炎症表型分类
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Inflammatory Endotypes of Chronic Rhinosinusitis in the Korean Population: Distinct Expression of Type 3 Inflammation.韩国人群慢性鼻-鼻窦炎的炎症内型：3型炎症的独特表达
Allergy Asthma Immunol Res. 2023 Jul;15(4):437-450. doi: 10.4168/aair.2023.15.4.437. Epub 2023 Jan 26.
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Treatment Strategy of Uncontrolled Chronic Rhinosinusitis with Nasal Polyps: A Review of Recent Evidence.未经控制的慢性鼻-鼻窦炎伴鼻息肉的治疗策略：近期证据回顾。
Int J Mol Sci. 2023 Mar 6;24(5):5015. doi: 10.3390/ijms24055015.
9
Retinoic acid promotes fibrinolysis and may regulate polyp formation.视黄酸促进纤维蛋白溶解，可能调节息肉形成。
J Allergy Clin Immunol. 2022 Nov;150(5):1114-1124.e3. doi: 10.1016/j.jaci.2022.05.021. Epub 2022 Jun 18.
10
Nasal secretion tissue plasminogen activator: A novel effective predictor of nasal polyp recurrence.鼻分泌物组织型纤溶酶原激活剂：鼻息肉复发的一种新型有效预测指标。
J Allergy Clin Immunol Pract. 2022 Aug;10(8):2191-2194.e3. doi: 10.1016/j.jaip.2022.04.031. Epub 2022 May 5.

本文引用的文献

1
Increased thrombin-activatable fibrinolysis inhibitor levels in patients with chronic rhinosinusitis with nasal polyps.慢性鼻-鼻窦炎伴鼻息肉患者中凝血酶激活的纤溶抑制物水平升高。
J Allergy Clin Immunol. 2019 Dec;144(6):1566-1574.e6. doi: 10.1016/j.jaci.2019.08.040. Epub 2019 Sep 25.
2
Nattokinase, profibrinolytic enzyme, effectively shrinks the nasal polyp tissue and decreases viscosity of mucus.纳豆激酶，纤维蛋白溶解酶，能有效缩小鼻息肉组织并降低黏液的粘性。
Allergol Int. 2017 Oct;66(4):594-602. doi: 10.1016/j.alit.2017.03.007. Epub 2017 Apr 4.
3
Heterogeneous inflammatory patterns in chronic rhinosinusitis without nasal polyps in Chicago, Illinois.伊利诺伊州芝加哥市非鼻息肉慢性鼻-鼻窦炎的异质性炎症模式。
J Allergy Clin Immunol. 2017 Feb;139(2):699-703.e7. doi: 10.1016/j.jaci.2016.06.063. Epub 2016 Sep 14.
4
Diversity of T cytokine profiles in patients with chronic rhinosinusitis: A multicenter study in Europe, Asia, and Oceania.慢性鼻-鼻窦炎患者 T 细胞因子谱的多样性：一项在欧洲、亚洲和大洋洲进行的多中心研究。
J Allergy Clin Immunol. 2016 Nov;138(5):1344-1353. doi: 10.1016/j.jaci.2016.05.041. Epub 2016 Jul 15.
5
Features of airway remodeling in different types of Chinese chronic rhinosinusitis are associated with inflammation patterns.不同类型中国慢性鼻-鼻窦炎的气道重塑特征与炎症模式相关。
Allergy. 2013 Jan;68(1):101-9. doi: 10.1111/all.12064. Epub 2012 Nov 16.
6
Excessive fibrin deposition in nasal polyps caused by fibrinolytic impairment through reduction of tissue plasminogen activator expression.纤维蛋白溶解功能障碍导致组织型纤溶酶原激活物表达减少引起鼻息肉中纤维蛋白过度沉积。
Am J Respir Crit Care Med. 2013 Jan 1;187(1):49-57. doi: 10.1164/rccm.201207-1292OC. Epub 2012 Nov 15.
7
Role of thrombin in chronic rhinosinusitis-associated tissue remodeling.凝血酶在慢性鼻-鼻窦炎相关组织重塑中的作用。
Am J Rhinol Allergy. 2011 Jan-Feb;25(1):7-11. doi: 10.2500/ajra.2011.25.3535.
8
Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese.中国成年患者不同类型慢性鼻-鼻窦炎的独特免疫病理特征
J Allergy Clin Immunol. 2009 Sep;124(3):478-84, 484.e1-2. doi: 10.1016/j.jaci.2009.05.017. Epub 2009 Jul 9.
9
Nasal polyposis: from cytokines to growth.鼻息肉病：从细胞因子到生长
Am J Rhinol. 2000 Sep-Oct;14(5):279-90. doi: 10.2500/105065800781329573.

Common fibrin deposition and tissue plasminogen activator downregulation in nasal polyps with distinct inflammatory endotypes.

作者信息

Chen Cai-Ling, Yao Yin, Pan Li, Hu Si-Tao, Ma Jin, Wang Zhi-Chao, Kern Robert C, Schleimer Robert P, Liu Zheng

机构信息

Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Deprtment of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Ill.

出版信息

J Allergy Clin Immunol. 2020 Sep;146(3):677-681. doi: 10.1016/j.jaci.2020.02.010. Epub 2020 Feb 26.

DOI:10.1016/j.jaci.2020.02.010
PMID:32112792
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9187142/
Abstract
摘要