Lusiana Retno Ariadi, Nuryanto Rahmad, Muna Nailul, Dayanti Dilla, Kiswandono Agung Abadi, Annisa Riska Nurfirda, Septevani Athanasia Amanda, Sasongko Nurwarrohman Andre
Department of Chemistry, Faculty of Science and Mathematics, Diponegoro University, 50275 Semarang, Indonesia.
Department of Chemistry, Faculty of Science and Mathematics, Diponegoro University, 50275 Semarang, Indonesia.
Int J Biol Macromol. 2024 Mar;261(Pt 2):129784. doi: 10.1016/j.ijbiomac.2024.129784. Epub 2024 Feb 1.
Membrane-based polyether sulfone (PES) is a potential candidate for hemodialysis because of its properties such as high mechanical strength, thermal stability, and chemical resistance. However, the nature of the hydrophobicity in the PES membrane inhibits their performance in transporting creatinine. In this study, polyethersulfone (PES) membranes were modified using a sulfonation process and the addition of chitosan (CS) and lithium chloride (LiCl) to improve its performance in transporting creatinine. The FTIR spectrum of the modified membrane shows peaks of the sulfonate (-SO), amine (NH), and hydroxyl (-OH) groups in absorption areas of 1065 cm, 1650 cm, and 3384 cm, respectively, indicating that the membrane SPES/CS-LiCl has been successfully prepared. The modified PES membranes shows a higher porosity, swelling, water absorption, and hydrophilicity than pure PES membrane. The modification of the PES membrane in this study also enhances the ability of the membrane to transport creatinine. In the pure PES membrane, the creatinine clearance is 0.30 mg/dL, while in the SPES/CS-LiCl (5:2) membrane the creatinine clearance is 0.42 mg/dL.
基于膜的聚醚砜（PES）因其具有高机械强度、热稳定性和耐化学性等特性，是血液透析的潜在候选材料。然而，PES膜的疏水性本质抑制了其在转运肌酐方面的性能。在本研究中，通过磺化工艺以及添加壳聚糖（CS）和氯化锂（LiCl）对聚醚砜（PES）膜进行改性，以提高其转运肌酐的性能。改性膜的傅里叶变换红外光谱（FTIR）在1065 cm、1650 cm和3384 cm的吸收区域分别显示出磺酸根（-SO）、胺基（NH）和羟基（-OH）基团的峰，表明成功制备了膜SPES/CS-LiCl。改性后的PES膜比纯PES膜具有更高的孔隙率、溶胀度、吸水率和亲水性。本研究中对PES膜的改性还增强了膜转运肌酐的能力。在纯PES膜中，肌酐清除率为0.30 mg/dL，而在SPES/CS-LiCl（5:2）膜中，肌酐清除率为0.42 mg/dL。
