Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA.
Department of Aquatic Health Sciences, Virginia Institute of Marine Science, William & Mary, P.O. Box 1346, Gloucester Point, VA 23062, USA.
Harmful Algae. 2020 Feb;92:101707. doi: 10.1016/j.hal.2019.101707. Epub 2020 Jan 16.
In 1968 Burkholder and associates (J. Antibiot. (Tokyo)1968, 21, 659-664) isolated the antifungal toxin goniodomin from an unidentified Puerto Rican dinoflagellate and partially characterized its structure. Subsequently, a metabolite of Alexandrium hiranoi was isolated by Murakami et al. from a bloom in Japan and its structure was established (Tetrahedron Lett.1988, 29, 1149-1152). The Japanese substance had strong similarities to Burkholder's but due to uncertainty as to whether it was identical or only similar, Murakami named his toxin goniodomin A. A detailed study of this question now provides compelling evidence that Burkholder's goniodomin is identical to goniodomin A. Morphological characterization of the dinoflagellate suggests that it was the genus Alexandrium but insufficient evidence is available to make a definite identification of the species. This is the only report of goniodomin in the Caribbean region.
1968 年，Burkholder 等人（J. Antibiot. (Tokyo)1968, 21, 659-664）从一种未鉴定的波多黎各甲藻中分离出抗真菌毒素 goniodomin，并对其结构进行了部分表征。随后，Murakami 等人从日本的一次赤潮中分离出亚历山大藻的一种代谢物，并确定了其结构（Tetrahedron Lett.1988, 29, 1149-1152）。日本的这种物质与 Burkholder 的物质非常相似，但由于不确定它们是否相同或只是相似，Murakami 将他的毒素命名为 goniodomin A。现在对这个问题的详细研究提供了令人信服的证据，证明 Burkholder 的 goniodomin 与 goniodomin A 完全相同。对甲藻的形态学特征进行了表征，表明它是亚历山大藻属，但没有足够的证据可以对其种进行明确的鉴定。这是加勒比地区 goniodomin 的唯一报道。
