异 Rugosiformin A-F，六种来自 Rugosiformis 的 ent-kaurane 二萜。
Isorugosiformins A-F, six ent-kaurane diterpenoids from Isodon rugosiformis.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, People's Republic of China.
出版信息
Fitoterapia. 2020 Apr;142:104529. doi: 10.1016/j.fitote.2020.104529. Epub 2020 Feb 28.
Six new ent-kaurane diterpenoids, isorugosiformins A-F (1-6), were isolated from the aerial parts of Isodon rugosiformis Hand.-Mazz. Hara. Their structures were elucidated by spectroscopic data interpretation, single crystal X-ray diffraction, and quantum chemical calculation of NMR parameters. The absolute configuration of 5 as 6R was the first case in the known 6,7:8,15-diseco-7,20-olide-6,8-cyclo-ent-kaurane diterpenoids.
从糙苏属植物糙苏中分离得到了六个新的-ent-贝壳杉烷二萜类化合物，分别命名为isorugosiformins A-F（1-6）。通过光谱数据分析、单晶 X 射线衍射和 NMR 参数的量子化学计算，确定了它们的结构。化合物 5 的绝对构型为 6R，这在已知的 6,7:8,15-去甲-7,20-内酯-6,8-环-ent-贝壳杉烷二萜中尚属首例。
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