Zhang Hai Bo, Pu Jian Xin, Zhao Yong, He Fei, Zhao Wei, Lou Li Guang, Xiao Wei Lie, Sun Han Dong
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Nat Prod Commun. 2010 Dec;5(12):1873-6.
Three new 18-oxygenated ent-kaurane diterpenoids, isoleuconins A-C (1-3) and ten known diterpenoids were isolated from the aerial parts of Isodon leucophyllus. The structures were elucidated by 1D and 2D NMR spectroscopic analysis. All of the compounds were evaluated for their cytotoxicity. Rabdokunmin A (13) showed significant cytotoxicity against HT-29 cells, with an IC50 value of 6.2 microM.
从白毛香茶菜的地上部分分离得到3个新的18-氧化对映-贝壳杉烷二萜类化合物，异亮叶甲素A-C（1-3）以及10个已知的二萜类化合物。通过一维和二维核磁共振光谱分析确定了它们的结构。对所有化合物进行了细胞毒性评估。拉布多昆明A（13）对HT-29细胞显示出显著的细胞毒性，IC50值为6.2微摩尔。
