Department of Psychiatry, Shri Guru Ram Rai Institute of Medical & Health Sciences, Dehradun, Uttrakhand, India.
Department of Psychiatry, Lokopriya Gopinath Bordoloi Regional Institute of Mental Health, Tezpur, Assam, India.
Asian J Psychiatr. 2020 Jun;51:101967. doi: 10.1016/j.ajp.2020.101967. Epub 2020 Feb 14.
Association between leptin plasma levels and alcohol craving has been seen previously. This study aims to research this correlation in a different population while comparing this correlation with respect to hyper-excitable state of alcohol withdrawal.
25 patients of alcohol dependence were assessed for withdrawal symptoms and craving for alcohol. Leptin levels were measured on 1 day, @ the end of 1 week, @ the end of 3 week of stopping alcohol. Withdrawal was assessed using CIWA-A at day 1 and day 7, craving was assessed using PENN's scale of craving at week 1 and week 3. Control group consisted of 15 first degree relatives.
Leptin levels [t (38) = 2.95, p = 0.005] was significantly higher in alcohol dependent patients. Levels had no significant correlation with alcohol withdrawal scores [Leptin/BMI and CIWA Ar: r = 0.18, p = 0.40 on day 1] but had positive correlation with craving scores [Leptin/BMI and PACS: r = 0.684, p = 0.001].
This study shows that leptin, known for balancing the energy homeostasis of body, also seem to play a role in pathways of drug dependence and craving. This relation is independent of stress hormone axis.
先前已有研究表明，瘦素血浆水平与酒精渴求之间存在关联。本研究旨在研究另一人群中这种相关性，并比较其与酒精戒断时过度兴奋状态的相关性。
评估 25 名酒精依赖患者的戒断症状和酒精渴求程度。在停止饮酒的第 1 天、第 1 周结束时和第 3 周结束时测量瘦素水平。第 1 天和第 7 天使用 CIWA-A 评估戒断情况，第 1 周和第 3 周使用 PENN 渴求量表评估渴求程度。对照组由 15 名一级亲属组成。
酒精依赖患者的瘦素水平[ t (38) = 2.95, p = 0.005]显著升高。水平与酒精戒断评分无显著相关性[瘦素/体重指数和 CIWA Ar：第 1 天 r = 0.18, p = 0.40]，但与渴求评分呈正相关[瘦素/体重指数和 PACS：r = 0.684, p = 0.001]。
本研究表明，瘦素作为平衡身体能量稳态的物质，似乎也在药物依赖和渴求的途径中发挥作用。这种关系与应激激素轴无关。
