失语型进行性失语症中语音错误的神经解剖学相关性。
Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia.
机构信息
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
出版信息
Brain Lang. 2020 May;204:104773. doi: 10.1016/j.bandl.2020.104773. Epub 2020 Feb 27.
Abstract
While phonologic errors may be one of the salient features of the logopenic variant of primary progressive aphasia (lvPPA), sparse data are available on their neuroimaging correlates. The purpose of this study was to identify brain regions associated with different types of phonologic errors across several tasks for participants with lvPPA. Correlational analyses between phonologic errors across tasks most likely to elicit such errors and specific left hemisphere gray matter volume regions were conducted for 20 participants. Findings point to the inferior parietal lobe and supramarginal gyrus as being the most relevant correlates. Atrophy in these regions may increase the likelihood of making phonologic errors in lvPPA, particularly substitution error types. Our results provide support for neuroanatomical correlates of phonologic errors in the parietal region, which is consistent with previous findings of temporoparietal cortex involvement/atrophy in lvPPA.
摘要
虽然语音错误可能是主要进行性失语症（lvPPA）的流利型变体的显著特征之一，但关于其神经影像学相关性的数据很少。本研究的目的是确定与 lvPPA 参与者在多个任务中不同类型的语音错误相关的大脑区域。对 20 名参与者进行了跨任务语音错误与特定左侧半球灰质体积区域之间的相关性分析，这些任务最有可能引起此类错误。研究结果表明，下顶叶和缘上回是最相关的区域。这些区域的萎缩可能会增加 lvPPA 中出现语音错误的可能性，尤其是替代错误类型。我们的研究结果为语音错误在顶叶区域的神经解剖学相关性提供了支持，这与 lvPPA 中颞顶叶皮质受累/萎缩的先前发现一致。
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