Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Vietnam.
Center of Excellence in Behavioral Medicine, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam.
Dement Geriatr Cogn Disord. 2019;48(5-6):221-233. doi: 10.1159/000505741. Epub 2020 Feb 28.
Alzheimer's disease (AD) with its high burden on disability is known as one of the critical public health issues worldwide. Hence, providing comprehensive care and effective symptomatic treatment are becoming a challenge for many healthcare systems. Quality of life (QOL) has been identified as an important indicator to develop holistic care for people living with AD since it reflects treatment response, the progression of AD, and activities of daily living. This study aimed to identify research trends and landscapes as well as important factors in QOL studies in the field of AD.
English research was extracted from the online database Web of Science to analyze research publications' growth rate and content on AD and QOL. VOSviewer was used to visualize the correlations between terms in titles and abstracts. Research topics were created using Latent Dirichlet Allocation of abstracts' content and disciplines. Major landscapes in the QOL assessment included care and treatment for AD in epidemiological studies and clinical trials. Besides, most studies were conducted in high-income countries, such as the USA or the United Kingdom. Findings of our study also identified a lack of contextualized factors and research gaps in terms of QOL among individuals with AD. Key Messages: Further studies should be conducted taking an effort to assess QOL among demented patients as well as advancing knowledge, attitude, and practice among family caregivers.
阿尔茨海默病（AD）的致残负担较高，是全球重大公共卫生问题之一。因此，为 AD 患者提供全面的护理和有效的对症治疗已成为许多医疗体系面临的挑战。生活质量（QOL）已被确定为 AD 患者整体护理的重要指标，因为它反映了治疗反应、AD 的进展以及日常生活活动。本研究旨在确定 AD 领域 QOL 研究的研究趋势和领域以及重要因素。
从在线数据库 Web of Science 中提取英文研究，以分析 AD 和 QOL 研究出版物的增长率和内容。VOSviewer 用于可视化标题和摘要中术语之间的相关性。使用抽象内容和学科的潜在狄利克雷分配来创建研究主题。QOL 评估的主要领域包括流行病学研究和临床试验中 AD 的护理和治疗。此外，大多数研究是在高收入国家进行的，例如美国或英国。我们研究的结果还确定了在 AD 个体中 QOL 方面缺乏情境化因素和研究差距。关键信息：应进一步开展研究，努力评估痴呆患者的 QOL，并提高家庭护理人员的知识、态度和实践水平。
