Department of Psychiatry, Faculty of Medicine, Health Sciences University, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey. E-mail.
Saudi Med J. 2020 Mar;41(3):275-282. doi: 10.15537/smj.2020.3.24909.
To assess obsessive-compulsive disorder (OCD) comorbidity and obsessive-compulsive symptom (OCS) dimensions in patients with schizophrenia.
This cross-sectional study included 300 patients with schizophrenia who were applied to the to the Outpatient Psychiatry Clinic of Health Sciences University Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey between July and December 2018. Data collection forms created by researchers were applied to the individuals. Obsessive-compulsive symptom were assessed with the Yale-Brown Obsessive Compulsive Scale (YBOCS) and the Dimensional Obsessive Compulsive Scale (DOCS).
The OCD prevalence was 17% (n=50) in the whole group while 10% (n=24/250) of the patients without OCD had 8-15 points at YBOCS. One-way ANOVA test revealed that the patients with OCD showed more severe positive, negative, and depressive symptoms, and also had lower functionality compared to those without OCD (p less than 0.05). The most severe OCS dimension was unacceptable obsessional thoughts in the patients with OCD and OCS. The severity of unacceptable obsessional thoughts was positively correlated with the depressive symptom severity, and negatively correlated with onset age of OCD and insight level in Pearson correlation analysis.
Patients with schizophrenia should be evaluated for presence of the OCS/OCD comorbidity in clinical practice. In addition, dimensional assessment of OCS might provide a different viewpoint on the presence of OCS/OCD in schizophrenia.
评估精神分裂症患者中强迫症(OCD)共病和强迫症状(OCS)维度。
本横断面研究纳入了 2018 年 7 月至 12 月期间在土耳其安卡拉卫生科学大学 Dışkapı Yıldırım Beyazıt 培训与研究医院门诊精神病学诊所就诊的 300 名精神分裂症患者。研究人员制定的数据采集表用于评估患者。使用耶鲁-布朗强迫量表(YBOCS)和多维强迫量表(DOCS)评估强迫症状。
全组 OCD 患病率为 17%(n=50),而无 OCD 的患者中有 10%(n=24/250)在 YBOCS 上得分为 8-15 分。单因素方差分析显示,与无 OCD 的患者相比,患有 OCD 的患者表现出更严重的阳性、阴性和抑郁症状,且功能更差(p<0.05)。在患有 OCD 和 OCS 的患者中,最严重的 OCS 维度是无法接受的强迫性思维。不可接受的强迫性思维的严重程度与抑郁症状的严重程度呈正相关,与 OCD 的发病年龄和 Pearson 相关分析中的洞察力水平呈负相关。
在临床实践中,应评估精神分裂症患者是否存在 OCS/OCD 共病。此外,OCS 的维度评估可能为精神分裂症中存在 OCS/OCD 提供不同的视角。