Catholic Institute of Smart Healthcare Center, Institute of Biomedical Industry, The Catholic University of Korea, Seoul, Korea.
Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
Korean J Intern Med. 2021 Mar;36(2):382-391. doi: 10.3904/kjim.2019.171. Epub 2020 Mar 5.
BACKGROUND/AIMS: We examined the concordance rate among fasting plasma glucose (FPG), 2-hour post-challenge glucose (2hr PG), and hemoglobin A1c (HbA1c) in the diagnosis of diabetes in a population with a high-risk for type 2 diabetes mellitus (T2DM) in Korea.
Among the participants from the Korean Diabetes Prevention Study, individuals with FPG ≥ 100 mg/dL, body mass index (BMI) ≥ 23.0 kg/m2, and no previous history of T2DM were consecutively enrolled after a 75 g glucose tolerance test. We analyzed the differences in the clinical characteristics in subjects with stage 1 (FPG, 100 to 109 mg/dL) and stage 2 (FPG, 110 to 125 mg/dL) impaired fasting glucose (IFG).
Of 1,637 participants, 27.2% had T2DM and 59.3% had IFG and/or impaired glucose tolerance (IGT). The mean age was 55.0 ± 8.1 years and the mean BMI was 26.3 ± 2.7 kg/m2. Based on FPG criteria, 515 (31.4%) and 352 (21.5%) subjects were classified as having stage 1 and stage 2 IFG, respectively. The 19.0% of stage 1 and 43.5% of stage 2 subjects showed 2hr PG levels in the diabetic range. Even for those in the normal FPG range, 63 (9.5%) participants showed a 2hr PG level of ≥ 200 mg/dL. Of 446 subjects with newly-diagnosed diabetes, 340 (76.2%) showed FPG levels < 126 mg/dL.
The oral glucose tolerance test should be actively considered for Korean adults who are overweight or obese with the IFG range (FPG, 100 to 125 mg/ dL) to allow for early detection of diabetes and prompt intervention.
背景/目的：我们在韩国的 2 型糖尿病高危人群中，研究空腹血糖（FPG）、餐后 2 小时血糖（2hr PG）和糖化血红蛋白（HbA1c）在糖尿病诊断中的一致性。
在韩国糖尿病预防研究中，对接受 75g 葡萄糖耐量试验的参与者中，FPG≥100mg/dL、体重指数（BMI）≥23.0kg/m2且无 2 型糖尿病既往史的个体连续纳入。我们分析了空腹血糖受损（IFG）阶段 1（FPG，100-109mg/dL）和阶段 2（FPG，110-125mg/dL）患者的临床特征差异。
1637 名参与者中，27.2%患有 2 型糖尿病，59.3%患有 IFG 和/或糖耐量受损（IGT）。平均年龄为 55.0±8.1 岁，平均 BMI 为 26.3±2.7kg/m2。根据 FPG 标准，515（31.4%）和 352（21.5%）名患者分别被归类为有 IFG 阶段 1 和阶段 2。19.0%的阶段 1 和 43.5%的阶段 2患者的 2hr PG 水平处于糖尿病范围。即使在 FPG 正常范围内，也有 63（9.5%）名患者的 2hr PG 水平≥200mg/dL。在新诊断为糖尿病的 446 名患者中，340（76.2%）患者的 FPG 水平<126mg/dL。
对于超重或肥胖且 IFG 范围（FPG，100-125mg/dL）的韩国成年人，应积极考虑口服葡萄糖耐量试验，以早期发现糖尿病并及时干预。
