Biomechanics Labs of Orthopaedics Institute, Tianjin Hospital, Heping District Munan Road NO 155, Tianjin, 300050, China; Tianjin Medical University, Heping District Qixiangtai Road NO 22, Tianjin, 300070, China.
Biomechanics Labs of Orthopaedics Institute, Tianjin Hospital, Heping District Munan Road NO 155, Tianjin, 300050, China.
Injury. 2020 Apr;51(4):804-811. doi: 10.1016/j.injury.2020.02.072. Epub 2020 Feb 18.
The association between sarcopenia and risk of fracture remained controversial. This systematic review and meta-analysis was conducted to evaluate the association between sarcopenia and fracture incidence in the middle-aged and elderly people.
Web of Science, PubMed, EMBASE, and the Cochrane Library were searched. Weighted averages were reported as hazard risk (HR) values with 95% confidence interval (CI). Statistical heterogeneity scores were assessed with the standard Cochran's Q test and the I statistic.
A total of 5 cohort studies involving 27 990 participants were included in our study. The crude and adjusted effect sizes between sarcopenia and fracture were extracted from 2 and 5 studies, respectively. Sarcopenia was significantly associated with fracture incidence without adjusting covariates (crude HR, 1.69; 95% CI, 1.34-2.13). After adjusting for potential confounders, sarcopenia still demonstrated significant positive association with fracture (adjusted HR, 1.50;95%CI, 1.08-2.08). The sensitivity analysis confirmed the stability of the results. In the subgroup analysis of studies after adjusting covariates, there were significant associations between sarcopenia and fracture in the subgroups of male, older people, American and hip fracture patients.
Our meta-analysis found that sarcopenia was significantly associated with fracture in middle aged and elderly people. However, more homogeneous studies are needed to fully clarify the relationship between sarcopenia and fracture.
肌少症与骨折风险之间的关联仍存在争议。本系统评价和荟萃分析旨在评估中年和老年人肌少症与骨折发生率之间的关联。
检索了 Web of Science、PubMed、EMBASE 和 Cochrane Library。报告加权平均值作为风险比（HR）值，置信区间（CI）为 95%。使用标准 Cochran's Q 检验和 I 统计量评估统计异质性评分。
共有 5 项队列研究纳入了 27990 名参与者。从 2 项和 5 项研究中分别提取了肌少症与骨折之间的未校正和校正效果大小。在未调整协变量时，肌少症与骨折发生率显著相关（未校正 HR，1.69；95%CI，1.34-2.13）。调整潜在混杂因素后，肌少症与骨折仍呈显著正相关（校正 HR，1.50；95%CI，1.08-2.08）。敏感性分析证实了结果的稳定性。在调整协变量后的研究亚组分析中，肌少症与男性、老年人、美国人以及髋部骨折患者的骨折之间存在显著关联。
我们的荟萃分析发现，肌少症与中年和老年人的骨折显著相关。然而，需要更多同质的研究来充分阐明肌少症与骨折之间的关系。
