Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Bei-Hu Branch, Taiwan.
Community and Geriatric Medicine Research Center, National Taiwan University Hospital, Bei-Hu Branch, Taiwan.
Age Ageing. 2017 Sep 1;46(5):738-746. doi: 10.1093/ageing/afx094.
to explore whether sarcopenia is associated with depression.
electronic literature databases from PubMed, Scopus, Embase and Google Scholar were searched. A systematic review and meta-analysis of observational studies was conducted.
community and outpatient clinic.
people with and without diagnoses of sarcopenia.
outcome measures of depression.
about 15 articles were included, 5 of which were retrieved for narrative review. The crude odds ratios (ORs) between sarcopenia and depression were extracted from the remaining 10 studies, 6 of which also included adjusted ORs. Sarcopenia was associated with depression without adjusting covariates (crude OR, 1.640; 95% confidence interval (CI), 1.247-2.155). After adjusting for potential confounders such as age, gender, cognitive performance and physical activity, sarcopenia still demonstrated a significant positive association with depression (adjusted OR, 1.821; 95% CI, 1.160-2.859). A stratified analysis showed that the studies that used bioelectrical impedance analysis for measurement of body composition tended to have an elevated association between sarcopenia and depression compared with those that used dual-energy X-ray absorptiometry or equation estimation.
sarcopenia was independently associated with depression. The causal relationship between the two clinical conditions requires future validation with cohort studies.
探讨肌少症是否与抑郁相关。
检索了 PubMed、Scopus、Embase 和 Google Scholar 电子文献数据库。对观察性研究进行了系统综述和荟萃分析。
社区和门诊。
被诊断为肌少症和未被诊断为肌少症的人群。
抑郁的结局指标。
纳入了约 15 篇文章，其中 5 篇文章用于叙述性综述。从其余 10 项研究中提取了肌少症与抑郁之间的原始比值比（OR），其中 6 项研究还包括了调整后的 OR。在未调整混杂因素（如年龄、性别、认知表现和体力活动）的情况下，肌少症与抑郁相关（原始 OR，1.640；95%置信区间（CI），1.247-2.155）。在调整了年龄、性别、认知表现和体力活动等潜在混杂因素后，肌少症与抑郁仍呈显著正相关（调整后的 OR，1.821；95%CI，1.160-2.859）。分层分析表明，使用生物电阻抗分析测量身体成分的研究与使用双能 X 射线吸收法或方程估算的研究相比，肌少症与抑郁之间的关联更为显著。
肌少症与抑郁独立相关。这两种临床情况之间的因果关系需要进一步通过队列研究来验证。
