Department of Cardiology, University of Nebraska Medical Center, Omaha, Nebraska.
Department of Cardiology, Rush University Medical Center, Chicago, Illinois.
Ultrasound Med Biol. 2020 May;46(5):1071-1081. doi: 10.1016/j.ultrasmedbio.2020.01.004. Epub 2020 Feb 27.
Contrast echocardiography microbubbles are ultrasound-enhancing agents that were originally designed to help improve endocardial border definition, known as left ventricle opacification, and to enhance Doppler signals. Over time, contrast microbubbles are used to assess myocardial perfusion because they travel through the capillaries of the cardiac circulation. Current research provides good evidence that myocardial perfusion echocardiography improves comprehensive echocardiographic evaluations of ischemic heart disease. The approval of regulatory authorities and the availability of quantitative operator-independent analysis software will hopefully prompt physicians and sonographers to implement myocardial perfusion echocardiography into the daily workflow of echo laboratories. New diagnostic and therapeutic applications will result in improved patient care, especially in the area of sonothrombolysis, where preliminary data have already shown utilization in ST elevation myocardial infarction, improving left ventricular systolic function and reducing the need for implantable defibrillators at 6-mo follow-up. This review gives an overview of the applications of myocardial perfusion imaging with ultrasound. Each cited study had institutional review board/institutional animal care and use approval.
对比超声微泡是一种超声增强剂，最初设计用于帮助改善心内膜边界定义，即左心室显影，并增强多普勒信号。随着时间的推移，对比微泡被用于评估心肌灌注，因为它们可以穿过心脏循环的毛细血管。目前的研究提供了很好的证据，表明心肌灌注超声心动图可以改善缺血性心脏病的综合超声心动图评估。监管机构的批准和定量、独立于操作者的分析软件的可用性有望促使医生和超声技师将心肌灌注超声心动图纳入超声心动图实验室的日常工作流程。新的诊断和治疗应用将带来更好的患者护理，特别是在超声溶栓领域，初步数据已经表明在 ST 段抬高型心肌梗死中得到了应用，改善了左心室收缩功能，并减少了在 6 个月随访时需要植入除颤器的需求。这篇综述概述了超声心肌灌注成像的应用。每一项被引用的研究都得到了机构审查委员会/机构动物护理和使用批准。
