Laboratory of Metabolism and Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University.
Biol Pharm Bull. 2020;43(3):366-374. doi: 10.1248/bpb.b19-00837.
Selenoprotein P (SeP) is one of the 25 human selenocysteine (Sec)-containing proteins, and is generally thought to function as a plasma carrier of the trace element selenium in the body. Recent studies, however, indicate unsuspected pivotal roles of SeP in human diseases, particularly in type 2 diabetes mellitus (T2DM) and pulmonary arterial hypertension (PAH). In this review, we will summarize the characteristics of SeP and recent advances in the field, especially focusing on the emerging roles of SeP in pathophysiological conditions. We will also discuss potential medical/pharmaceutical applications targeting SeP.
硒蛋白 P（SeP）是 25 种人类含硒半胱氨酸（Sec）蛋白之一，通常被认为是体内痕量元素硒的血浆载体。然而，最近的研究表明，SeP 在人类疾病中，特别是 2 型糖尿病（T2DM）和肺动脉高压（PAH）中，具有意想不到的关键作用。在这篇综述中，我们将总结 SeP 的特征和该领域的最新进展，特别是重点介绍 SeP 在病理生理条件下的新兴作用。我们还将讨论针对 SeP 的潜在医学/药物应用。
