Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, No. 20, South Renmin Road, Section 3, Chengdu, 610041, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, 610041, China.
Biometals. 2024 Aug;37(4):943-953. doi: 10.1007/s10534-024-00586-1. Epub 2024 Feb 17.
Trace elements are important components in the body and have fundamental roles in maintaining a healthy and balanced pregnancy process. Either deficiency or excess of trace elements, including selenium, iron, zinc, copper, and magnesium can lead to pregnancy complications. As a rare disorder during pregnancy of unknown aetiology, intrahepatic cholestasis of pregnancy (ICP) poses a significant risk to the fetus of perinatal mortality. ICP is a multifactorial complication of which the pathogenesis is still an enigma. Epidemiological studies have demonstrated the association of ICP with some trace elements. Evidence from retrospective studies in humans further revealed the possible contributing roles of trace elements in the pathogenesis of ICP. The published literature on the association of trace elements with ICP was reviewed. Recent advances in molecular biological techniques from animal studies have helped to elucidate the possible mechanisms by how these trace elements function in regulating oxidative reactions, inflammatory reactions and immune balance in the maternal-fetal interface, as well as the influence on hepato-intestinal circulation of bile acid. The scenario regarding the role of trace elements in the pathogenesis of ICP is still developing. The administration or depletion of these trace elements may have promising effects in alleviating the symptoms and improving the pregnancy outcomes of ICP.
微量元素是体内的重要组成部分，在维持健康和平衡的妊娠过程中起着基础性作用。包括硒、铁、锌、铜和镁在内的微量元素的缺乏或过量，都会导致妊娠并发症。作为一种妊娠期间病因不明的罕见疾病，妊娠肝内胆汁淤积症（ICP）会给围产期胎儿死亡率带来重大风险。ICP 是一种多因素并发症，其发病机制仍然是一个谜。流行病学研究表明，ICP 与一些微量元素有关。来自人类回顾性研究的证据进一步揭示了微量元素在 ICP 发病机制中的可能作用。本文对与 ICP 相关的微量元素的文献进行了综述。动物研究中分子生物学技术的最新进展有助于阐明这些微量元素在调节母体-胎儿界面的氧化反应、炎症反应和免疫平衡以及对肝胆循环中胆汁酸的影响方面的作用机制。关于微量元素在 ICP 发病机制中的作用的情况仍在发展中。这些微量元素的补充或缺乏可能对缓解 ICP 症状和改善妊娠结局有一定的效果。
