Li A K, Trenchev P S, Holborow E J, Newsome C, Wynne A T
Clin Exp Immunol. 1977 Feb;27(2):273-7.
Attempts were made to induce smooth muscle antibody (SMA) in rats by various procedures causing cell necrosis. Ligation of a liver lobe and cryosurgical damage to a liver lobe both resulted in subsequent appearance of SMA, provided the damage tissue was not removed. Transfer of the damaged liver tissue to the peritoneal cavity of a normal rat did not result in SMA production in the recipient. The SMA produced showed anti-actin and anti-heavy meromyosin specificity. Damage induced by hepatotoxic agents failed to give rise to SMA.
人们尝试通过各种导致细胞坏死的方法在大鼠体内诱导产生平滑肌抗体（SMA）。肝叶结扎和肝叶冷冻手术损伤均导致随后出现SMA，前提是损伤组织未被移除。将受损肝组织转移至正常大鼠的腹腔并未导致受体产生SMA。所产生的SMA表现出抗肌动蛋白和抗重酶解肌球蛋白特异性。肝毒性药物诱导的损伤未能产生SMA。
