Kamatham Saivaishnavi, Shahjehan Faisal, Kasi Pashtoon Murtaza
Department of Cancer Biology/Pathology, Wayne State University, Detroit, MI, United States.
Department of Internal Medicine, Conemaugh Memorial Medical Center, Johnstown, PA, United States.
Front Pharmacol. 2020 Feb 10;11:23. doi: 10.3389/fphar.2020.00023. eCollection 2020.
Pancreatic cancer is an aggressive malignancy with poor survival. Research has indicated the association of few genetic aberrations with pancreatic cancer. The data regarding the prevalence of microsatellite instability in pancreatic cancer is diverse and controversial. However, it could be an actionable target in pancreatic cancer especially due to availability of immune checkpoint inhibitors which has demonstrated promising results in different types of cancers. We present a case of pancreatic cancer whose microsatellite instability status was identified on liquid biopsy (circulating tumor DNA testing). Our patient showed a dramatic ongoing durable response to immunotherapy. We were able to do serial monitoring with liquid biopsy that showed clinical utility and validity.
胰腺癌是一种侵袭性恶性肿瘤，生存率低。研究表明，很少有基因畸变与胰腺癌相关。关于胰腺癌微卫星不稳定性患病率的数据多样且存在争议。然而，它可能是胰腺癌的一个可操作靶点，特别是由于免疫检查点抑制剂的出现，其已在不同类型癌症中显示出有前景的结果。我们报告一例通过液体活检（循环肿瘤DNA检测）确定微卫星不稳定性状态的胰腺癌病例。我们的患者对免疫治疗表现出持续显著的持久反应。我们能够通过液体活检进行连续监测，显示出临床实用性和有效性。
