Department of Orthopedics and Trauma Surgery, Patan Academy of Health Sciences, Lalitpur, Nepal.
Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
Clin Orthop Surg. 2020 Mar;12(1):9-21. doi: 10.4055/cios.2020.12.1.9. Epub 2020 Feb 13.
Distal radius fractures (DRFs) are one of the most common fractures seen in elderly people. Patients with DRFs have a high incidence of osteoporosis and an increased risk of subsequent fractures, subtle early physical performance changes, and a high prevalence of sarcopenia. Since DRFs typically occur earlier than vertebral or hip fractures, they reflect early changes of the bone and muscle frailty and provide physicians with an opportunity to prevent progression of frailty and secondary fractures. In this review, we will discuss the concept of DRFs as a medical condition that is at the start of the fragility fracture cascade, recent advances in the diagnosis of bone fragility including emerging importance of cortical porosity, fracture healing with osteoporosis medications, and recent progress in research on sarcopenia in patients with DRFs.
桡骨远端骨折（DRFs）是老年人中最常见的骨折之一。DRF 患者骨质疏松症发病率高，后续骨折风险增加，早期身体机能变化细微，以及肌肉减少症的患病率高。由于 DRF 通常比椎体或髋部骨折发生得更早，因此它们反映了骨骼和肌肉脆弱的早期变化，并为医生提供了预防脆弱性进展和继发性骨折的机会。在这篇综述中，我们将讨论 DRF 作为一种疾病状态的概念，即脆性骨折级联的开始，包括皮质多孔性的新兴重要性在内的骨脆弱性诊断的最新进展，骨质疏松症药物治疗下的骨折愈合，以及 DRF 患者肌肉减少症研究的最新进展。
