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哥伦比亚国立癌症研究所采用细胞减灭术和腹腔内热化疗治疗胆管癌腹膜转移

Peritoneal Metastasis of Cholangiocarcinoma Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy at the Instituto Nacional de Cancerología, Colombia.

作者信息

Hernandez Dary L, Restrepo Juliana, Garcia Mora Mauricio

机构信息

Surgical Oncology, Instituto Nacional de Cancerologia, Bogotá D.C., COL.

Surgical Oncology, Instituto Nacional de Cancerología, Bogotá D.C., COL.

出版信息

Cureus. 2020 Jan 18;12(1):e6697. doi: 10.7759/cureus.6697.

DOI:10.7759/cureus.6697
PMID:32117649
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7029824/
Abstract

Cholangiocarcinoma is a low-frequency neoplasm of onset with a poor prognosis. Peritoneal carcinomatosis is the most frequent site of metastasis with a standard palliative chemotherapy treatment. In the present article, we describe the case of a 35-year-old woman with peritoneal carcinomatosis secondary to an intrahepatic cholangiocarcinoma who was treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as a non-standard therapeutic method. The patient has disease-free survival of 12 months with very good quality of life. The treatment of peritoneal metastasis from cholangiocarcinoma by CRS and HIPEC is feasible and could proportion better survival to these patients compared to systemic palliative chemotherapy. These therapeutic modalities can complement each other.

摘要

胆管癌是一种发病率低且预后不良的肿瘤。腹膜转移癌是最常见的转移部位,采用标准的姑息化疗治疗。在本文中,我们描述了一名35岁女性的病例,该患者因肝内胆管癌继发腹膜转移癌,接受了减瘤手术(CRS)和腹腔内热灌注化疗(HIPEC),这是一种非标准治疗方法。该患者无病生存12个月,生活质量良好。与全身姑息化疗相比,采用CRS和HIPEC治疗胆管癌腹膜转移是可行的,并且可以为这些患者带来更好的生存。这些治疗方式可以相互补充。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e69/7029824/7396a44c5b3e/cureus-0012-00000006697-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e69/7029824/68496b66069e/cureus-0012-00000006697-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e69/7029824/7396a44c5b3e/cureus-0012-00000006697-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e69/7029824/68496b66069e/cureus-0012-00000006697-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4e69/7029824/7396a44c5b3e/cureus-0012-00000006697-i02.jpg

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本文引用的文献

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Cytoreductive surgery and HIPEC improve survival compared to palliative chemotherapy for biliary carcinoma with peritoneal metastasis: A multi-institutional cohort from PSOGI and BIG RENAPE groups.细胞减灭术和 HIPEC 相较于姑息性化疗可改善伴腹膜转移的胆道癌患者的生存:来自 PSOGI 和 BIG RENAPE 团体的多机构队列研究。
Eur J Surg Oncol. 2018 Sep;44(9):1378-1383. doi: 10.1016/j.ejso.2018.04.023. Epub 2018 Jun 19.
2
Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy in the Management of Colorectal Peritoneal Metastasis.细胞减灭术与热灌注腹腔内化疗在结直肠癌腹膜转移治疗中的应用
Surg Clin North Am. 2017 Jun;97(3):671-682. doi: 10.1016/j.suc.2017.01.013.
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Clinical practice guidelines for the management of biliary tract cancers 2015: the 2nd English edition.
《2015年胆道癌管理临床实践指南:第二版英文本》
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