Yuan Sheng, Huang Chuyu, Xu Yuanyue, Chen Dong, Chen Lei
The First Affiliated Hospital of Jinan University.
Second Clinical College of Medicine.
Medicine (Baltimore). 2020 Feb;99(9):e19117. doi: 10.1097/MD.0000000000019117.
As development of society and change of modern life style, the prevalence of lumbar disc herniation (LDH) has been increasing. Being a major cause of low back pain, sciatica and radicular leg pain, LDH imposes a heavy burden on both individual and society. Because of high surgically intervene rate, non-invasive (non-surgical) treatments are recommended for most cases. Acupuncture has the advantages of low risk, good effect and low cost which has been proven that could alleviate pain while physical therapy plays a major role in the treatment of LDH in the vast majority of countries. The aim of this systematic review is to evaluate the effectiveness and safety of acupuncture for LDH.
RCTs on ACU treating LDH will be searched from the following databases: PubMed, Web of science, EmBase, Cochrane Library, China National Knowledge Infrastructure, Wanfang data, from their inception to May 2020. The primary outcomes are verbal rating scale and functional disability. Two reviewers will independently exclude substandard articles and extract eligible data. The risk of bias will be assessed using the Cochrane Handbook 5.1.0 for Systematic Reviews of Interventions. Egger test will be used to assess the reporting bias. Heterogeneity will be evaluated by the I statistic and Q test. We will conduct the meta-analysis using Stata V12.0 to evaluate the effectiveness of ACU for LDH. In case of high heterogeneity, sensitivity analysis of different items and subgroup analysis will be performed. The Grading of Recommendations Assessment, Development, and Evaluation System will be used to assess the quality of evidence.
The results of this review will be submitted to a journal for publication.
This proposed systematic review will evaluate the effectiveness and safety of acupuncture for LDH.
PROSPERO (registration number CRD42019148272).
随着社会发展和现代生活方式的改变，腰椎间盘突出症（LDH）的患病率一直在上升。作为腰痛、坐骨神经痛和腿部放射性疼痛的主要原因，LDH给个人和社会都带来了沉重负担。由于手术干预率高，大多数病例推荐采用非侵入性（非手术）治疗。针灸具有风险低、效果好、成本低的优点，已被证明可以缓解疼痛，而物理治疗在绝大多数国家的LDH治疗中发挥着主要作用。本系统评价的目的是评估针灸治疗LDH的有效性和安全性。
将从以下数据库检索关于针灸治疗LDH的随机对照试验（RCTs）：PubMed、科学网、EmBase、Cochrane图书馆、中国知网、万方数据，检索时间从建库至2020年5月。主要结局指标为视觉模拟评分法和功能障碍。两名研究者将独立排除不合格文章并提取合格数据。将使用Cochrane干预措施系统评价手册5.1.0评估偏倚风险。将使用Egger检验评估报告偏倚。将通过I统计量和Q检验评估异质性。我们将使用Stata V12.0进行荟萃分析，以评估针灸治疗LDH的有效性。如果异质性高，将进行不同项目的敏感性分析和亚组分析。将使用推荐意见评估、制定与评价系统（GRADE）评估证据质量。
本评价结果将提交给某期刊发表。
本拟进行的系统评价将评估针灸治疗LDH的有效性和安全性。
PROSPERO（注册号CRD42019148272）
