Jin Young Ju, Park Bumjung, Park Il-Seok, Choi Hyo Geun
Department of Otorhinolaryngology-Head & Neck Surgery, Wonkwang University College of Medicine, Iksan.
Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medicine, Anyang.
Medicine (Baltimore). 2020 Feb;99(9):e19318. doi: 10.1097/MD.0000000000019318.
The purpose of this study was to investigate the association of herpes zoster infection with peptic ulcer disease in a Korean population.The Korean National Health Insurance Service selects samples directly from the entire Korean population database, and 1,125,691 participants with 114,369,638 medical claim codes were selected from the entire Korean population (50 million). A total of 127,802 peptic ulcer disease participants were matched with 127,802 control participants at a ratio of 1:1, considering age group, sex, income group, region of residence, hypertension, diabetes, and dyslipidemia. We analyzed stratified Cox proportional hazard models to calculate the hazard ratios of peptic ulcer with respect to herpes zoster. For subgroup analyses, we divided the participants by age, sex, and time periods after the index date.The rate of herpes zoster was higher in the peptic ulcer group (9.1% [11,669/127,802]) than in the control group (7.4% [9,397/127,802], P < .001). The adjusted hazard ratio of herpes zoster was 1.24 (95% CI = 1.21-1.28, P < .001). In subgroup analyses performed according to age and sex, all crude and adjusted hazard ratios of herpes zoster were higher in the peptic ulcer disease group than in the control group (each P < .05). In another subgroup analysis according to follow-up periods, the crude and adjusted hazard ratios of herpes zoster were higher in the peptic ulcer disease group than in the control group except for < 1 year periods after the index dates (each P < .001).The hazard ratios of herpes zoster were significantly increased in the peptic ulcer group compared with those in the control group in all age and sex groups.
本研究的目的是调查韩国人群中带状疱疹感染与消化性溃疡疾病之间的关联。韩国国民健康保险服务机构直接从整个韩国人口数据库中选取样本，从全体韩国人口（5000万）中选取了1125691名参与者，他们拥有114369638个医疗理赔代码。总共127802名消化性溃疡疾病参与者与127802名对照参与者按1:1的比例进行匹配，同时考虑年龄组、性别、收入组、居住地区、高血压、糖尿病和血脂异常情况。我们分析了分层Cox比例风险模型，以计算带状疱疹相关的消化性溃疡的风险比。对于亚组分析，我们按年龄、性别和索引日期后的时间段对参与者进行划分。消化性溃疡组的带状疱疹发病率（9.1%[11669/127802]）高于对照组（7.4%[9397/127802]，P<0.001）。带状疱疹的调整后风险比为1.24（95%CI = 1.21 - 1.28，P<0.001）。在按年龄和性别进行的亚组分析中，消化性溃疡疾病组中带状疱疹的所有粗风险比和调整后风险比均高于对照组（各P<0.05）。在另一项按随访期进行的亚组分析中，除索引日期后<1年的时间段外，消化性溃疡疾病组中带状疱疹的粗风险比和调整后风险比均高于对照组（各P<0.001）。在所有年龄和性别组中，消化性溃疡组中带状疱疹的风险比与对照组相比均显著增加。
