Min Chanyang, Yoo Dae Myoung, Kim Miyoung, Choi Hyo Geun
Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Korea.
School of Public Health, Seoul National University, Seoul, Korea.
Australas J Dermatol. 2021 May;62(2):183-189. doi: 10.1111/ajd.13534. Epub 2021 Feb 1.
BACKGROUND/OBJECTIVE: Although previous studies reported the relationship between psoriasis and herpes zoster, the number of study is not sufficient to support the conclusions. The purpose of this study was to evaluate the association between psoriasis and herpes zoster.
The data of a nationally representative Korean cohort collected in the Korean Health Insurance Review and Assessment (HIRA) System from 2002 to 2013 were used. Psoriasis was defined ≥ 2 International Classification of Diseases 10 revision (ICD-10) L40 codes. Among them, severe psoriasis was defined as psoriatic medication use, including acitretin, systemic corticosteroid, cyclosporine and methotrexate. Other psoriasis was defined as mild psoriasis. Herpes zoster was defined as ≥ 2 ICD-10 B02 codes or ≥ 1 B02 code with antiviral medication use. Psoriasis patients (n = 11 009) and control participants (n = 44 036) were matched 1:4 by age, sex, income and region of residence. A stratified Cox proportional hazard model was used stratified by age, sex, income and region of residence. Crude and adjusted hazard ratios (HRs) were calculated for the risk of herpes zoster in the total psoriasis group, mild psoriasis group, and severe psoriasis group and compared with those in each matched control group.
The HR for herpes zoster was higher in the psoriasis group than in control group (adjusted HR = 1.22, 95% CI = 1.12-1.33, P < 0.001). The findings were consistent between the mild psoriasis and severe psoriasis patients and their matched controls, and between male psoriasis patients in all age groups and their matched male controls.
Psoriasis may increase the risk of herpes zoster, especially in males.
背景/目的：尽管先前的研究报道了银屑病与带状疱疹之间的关系，但研究数量不足以支持这些结论。本研究的目的是评估银屑病与带状疱疹之间的关联。
使用了2002年至2013年在韩国健康保险审查与评估（HIRA）系统中收集的具有全国代表性的韩国队列数据。银屑病定义为≥2个国际疾病分类第10版（ICD-10）L40编码。其中，重度银屑病定义为使用银屑病药物，包括阿维A、全身性皮质类固醇、环孢素和甲氨蝶呤。其他银屑病定义为轻度银屑病。带状疱疹定义为≥2个ICD-10 B02编码或≥1个B02编码且使用抗病毒药物。银屑病患者（n = 11009）和对照参与者（n = 44036）按年龄、性别、收入和居住地区进行1:4匹配。采用分层Cox比例风险模型，按年龄、性别、收入和居住地区进行分层。计算总银屑病组、轻度银屑病组和重度银屑病组中带状疱疹风险的粗风险比和调整后风险比（HR），并与各匹配对照组进行比较。
银屑病组带状疱疹的HR高于对照组（调整后HR = 1.22，95%CI = 1.12 - 1.33，P < 0.001）。轻度银屑病和重度银屑病患者及其匹配对照组之间，以及所有年龄组的男性银屑病患者及其匹配男性对照组之间的结果一致。
银屑病可能增加带状疱疹的风险，尤其是在男性中。
