Kwon Sam Hyun, Lee Eun Jung, Yeo Cha Dong, Kim Min Gul, Kim Jong Seung, Noh Sang Jae, Kim Eun Ji, Kim Su Geun, Lee Jong-Hwan, Yoo Ji Seob, Koh Ji Hoon, Kim Byeong Jin
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Jeonbuk National University.
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital.
Medicine (Baltimore). 2020 May;99(20):e20337. doi: 10.1097/MD.0000000000020337.
To investigate the potential relationship between septal deviation (SD) and headache using nationwide representative cohort sample data.This study used a nationwide cohort sample from the Korean National Health Insurance Service database. The cohort sample was composed of 1 million patients, which is obtained by propensity score matching from 2002 to 2013. There were 9171 individuals in the SD group and 28243 in the control or no SD group. The Kaplan-Meier survival analysis, the log-rank test, and Cox proportional hazard regression analysis were used to calculate the incidence, survival curve, and hazard ratio of headache for each group.There were no statistically significant differences in sex (P = .7708), age (P = .991), residential area (P = .9626), or socioeconomic status (P = .9982) between the 2 groups. The survival curve between SD and control or no SD showed a statistically significant difference. The adjusted hazard ratio for headache incidence during the 10-year follow-up period of the SD group was 1.37 (95% CI: 1.31-1.43).This cohort study suggests that SD is associated with headache. Therefore, these findings suggest that septoplasty can be considered as 1 of the treatment option in SD patients with headache.
利用全国代表性队列样本数据研究鼻中隔偏曲（SD）与头痛之间的潜在关系。本研究使用了韩国国民健康保险服务数据库中的全国队列样本。该队列样本由100万名患者组成，是通过倾向得分匹配从2002年至2013年获取的。SD组有9171人，对照组或无SD组有28243人。采用Kaplan-Meier生存分析、对数秩检验和Cox比例风险回归分析来计算每组头痛的发病率、生存曲线和风险比。两组在性别（P = 0.7708）、年龄（P = 0.991）、居住地区（P = 0.9626）或社会经济地位（P = 0.9982）方面无统计学显著差异。SD组与对照组或无SD组之间的生存曲线显示出统计学显著差异。SD组在10年随访期内头痛发病率的调整后风险比为1.37（95%CI：1.31 - 1.43）。这项队列研究表明SD与头痛有关。因此，这些发现表明，对于有头痛的SD患者，鼻中隔成形术可被视为一种治疗选择。
