Hiltunen A J, Järbe T U, Wängdahl K
University of Uppsala, Department of Clinical Psychology, Sweden.
Pharmacol Biochem Behav. 1988 Jul;30(3):675-8. doi: 10.1016/0091-3057(88)90082-2.
Rectal temperature as well as unconditioned activity in an open-field (O-F) arena, and palpation-induced vocalization were examined in rats treated intraperitoneally with cannabinol (CBN, 17.5 or 56 mg/kg) and cannabidiol (CBD, 10 or 30 mg/kg), either singly or in combination. CBN singly resulted in hypothermia which was not attenuated by the addition of CBD. CBN reduced ambulation and rearing activities as compared to vehicle-treated rats. CBD in combination with CBN did not attenuate these effects; the CBD doses in themselves appeared inactive. Vocalization occurred to a significantly greater extent in the CBN singly-treated rats as compared to the controls and the CBD singly-treated rats. Thus, CBD did not counteract the temperature and open-field effects induced by CBN. This is discussed in relation to previous results from drug discrimination experiments.
对腹腔注射大麻酚（CBN，17.5或56毫克/千克）和大麻二酚（CBD，10或30毫克/千克）单独或联合用药的大鼠，检测其直肠温度、在旷场（O-F） arena中的非条件活动以及触诊诱发的发声情况。单独使用CBN会导致体温过低，添加CBD并不能减弱这种情况。与用赋形剂处理的大鼠相比，CBN减少了行走和竖毛活动。CBD与CBN联合使用并没有减弱这些作用；CBD剂量本身似乎没有活性。与对照组和单独使用CBD处理的大鼠相比，单独使用CBN处理的大鼠发声明显更多。因此，CBD并没有抵消CBN诱导的体温和旷场效应。结合药物辨别实验的先前结果对此进行了讨论。
