胃微循环中的组胺受体。
Histamine receptors in the gastric microcirculation.
作者信息
Guth P H, Smith E
出版信息
Gut. 1978 Nov;19(11):1059-63. doi: 10.1136/gut.19.11.1059.
Abstract
The types and functions of histamine receptors in the submucosal arterioles of the corpus and antrum of the cat and rat stomach were studied using an in vivo microscopy technique. Change in arteriolar diameter in response to superfusion of histamine with and without antagonists was measured by an image-splitting technique. H1 and H2 histamine receptors subserving vasodilatation were demonstrated in both the antral and corpus submucosal arterioles of the cat and rat. However, the H1 effect was predominant in the antrum (the H2 antagonist inhibited histamine dilatation only in the presence of the H1 antagonist), while H1 and H2 effects were approximately equal and independent in the corpus.
摘要
利用体内显微镜技术研究了猫和大鼠胃体及胃窦黏膜下小动脉中组胺受体的类型和功能。通过图像分割技术测量了在有或无拮抗剂的情况下，组胺灌流引起的小动脉直径变化。在猫和大鼠的胃窦及胃体黏膜下小动脉中均证实了介导血管舒张的H1和H2组胺受体。然而，H1效应在胃窦中占主导（H2拮抗剂仅在存在H1拮抗剂时才抑制组胺引起的血管舒张），而在胃体中H1和H2效应大致相等且相互独立。
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