Lewi H J, Carter D C
Gut. 1983 Jan;24(1):33-7. doi: 10.1136/gut.24.1.33.
The effects of both an H1 receptor antagonist and an H2 receptor antagonist on changes in monovalent ion flux induced by topical sodium taurocholate were studied in antrectomised dogs fashioned with a denervated fundic pouch. The magnitude of taurocholate-induced ion flux was unaffected by topical administration of H1 or H2 receptor antagonists Parenteral administration of H1 or H2 receptor antagonist given singly or in combination produced an increase in net luminal Na+ gain before taurocholate administration but failed to reduce the magnitude of taurocholate-induced ion flux. It is concluded that histamine receptors are unlikely to have a role in the induction of mucosal injury by bile salts.
在制作了去神经支配胃底囊的胃窦切除犬中，研究了H1受体拮抗剂和H2受体拮抗剂对牛磺胆酸钠局部诱导的单价离子通量变化的影响。牛磺胆酸钠诱导的离子通量大小不受H1或H2受体拮抗剂局部给药的影响。单独或联合给予H1或H2受体拮抗剂进行肠胃外给药，在给予牛磺胆酸钠之前可使管腔内净钠增加，但未能降低牛磺胆酸钠诱导的离子通量大小。得出的结论是，组胺受体不太可能在胆盐诱导的黏膜损伤中起作用。
