J Clin Invest. 2020 Apr 1;130(4):1615-1617. doi: 10.1172/JCI135712.
Parathyroid hormone (PTH) has complex effects on bone, including stimulating bone formation and regulating the hematopoietic stem cell (HSC) niche. In the current issue of the JCI, Li et al. demonstrated that the microbiome, through the production of short-chain fatty acids and in particular, butyrate, is necessary for the ability of PTH to increase osteoblast numbers and stimulate bone formation. In addition to implications for the treatment of osteoporosis with PTH analogs, this pathway may be part of a broader mechanism through which the microbiome serves its key function of modulating the immune system.
甲状旁腺激素（PTH）对骨骼具有复杂的影响，包括刺激骨形成和调节造血干细胞（HSC）龛位。在本期 JCI 中，Li 等人表明，微生物组通过产生短链脂肪酸，特别是丁酸盐，对于 PTH 增加成骨细胞数量和刺激骨形成的能力是必需的。除了对使用 PTH 类似物治疗骨质疏松症的意义外，该途径可能是微生物组发挥其调节免疫系统的关键功能的更广泛机制的一部分。
