Salvio Ana Gabriela, Stringasci Mirian Denise, Barreto Requena Michelle, Bagnato Vanderlei Salvador
Skin Department, Amaral Carvalho Cancer Hospital, Brazil.
Sao Carlos Institute of Physics, University of Sao Paulo, Brazil.
Photodiagnosis Photodyn Ther. 2020 Jun;30:101700. doi: 10.1016/j.pdpdt.2020.101700. Epub 2020 Feb 29.
The combination of multiple sessions of Photodynamic therapy (PDT) and surgery have been used to treat an extensive superficial lesion of squamous cell carcinoma in situ. Methyl aminolevulinate (MAL) mediated PDT was applied to reduce the tumoral area and a small surgical removal was performed to complete elimination of the lesion. The reduction of the tumor area avoided the need for a skin graft application as well as possible postoperative complications, offering a more favorable cosmetic outcome. Two-years of follow-up showed no recurrence. The case is interesting and demonstrate potentialities for the combined use of PDT and surgery.
多次光动力疗法（PDT）与手术相结合已被用于治疗广泛的原位鳞状细胞癌浅表病变。应用甲基氨基乙酰丙酸（MAL）介导的光动力疗法来缩小肿瘤面积，并进行小范围手术切除以彻底消除病变。肿瘤面积的缩小避免了植皮的需要以及可能的术后并发症，提供了更理想的美容效果。两年的随访显示无复发。该病例很有意义，并证明了光动力疗法与手术联合应用的潜力。
