Grin Mikhail, Suvorov Nikita, Ostroverkhov Petr, Pogorilyy Viktor, Kirin Nikita, Popov Alexander, Sazonova Anna, Filonenko Elena
Department of Chemistry and Technology of Biologically Active Compounds, Medicinal and Organic Chemistry, Institute of Fine Chemical Technologies, MIREA-Russian Technological University, 86 Vernadsky Avenue, Moscow, 119571 Russian Federation.
Center for Obstetrics, Gynecology and Perinatology Named After V.I.Kulakov, FSBI "National Medical Research, " Akademika Oparina Street, 4, Moscow, 117497 Russian Federation.
Biophys Rev. 2022 Jun 9;14(4):941-963. doi: 10.1007/s12551-022-00962-6. eCollection 2022 Aug.
When conducting combined therapy of malignant neoplasms, treatment methods with various mechanisms of antitumor effects are used, while an additive or even synergistic effect can be realized. Combination treatment regimens are aimed at increasing the efficiency and, above all, at the complete eradication of the tumor, which can be achieved either by suppressing the survival mechanisms in PDT-resistant tumor cells or by pre-attenuation of tumor cells so that they become more susceptible to subsequent PDT. Photodynamic therapy is an approved medical technology for the treatment of various malignant neoplasms, and several precancerous and non-cancer diseases. To date, numerous data have been published on the combined use of PDT with traditional and innovative methods of treatment. This review considers research in this area in recent years.
在进行恶性肿瘤的联合治疗时，会使用具有各种抗肿瘤作用机制的治疗方法，同时可以实现相加甚至协同效应。联合治疗方案旨在提高疗效，最重要的是实现肿瘤的完全根除，这可以通过抑制对光动力疗法（PDT）耐药的肿瘤细胞的生存机制，或者通过预先减弱肿瘤细胞使其对后续的光动力疗法更敏感来实现。光动力疗法是一种经批准用于治疗各种恶性肿瘤以及多种癌前和非癌疾病的医疗技术。迄今为止，已经发表了大量关于光动力疗法与传统和创新治疗方法联合使用的数据。本综述探讨了近年来该领域的研究情况。
