Pérez Ajami Rasha Isabel, Carrión Sari Silvia Karina, Aliaga Mazas Yolanda, Calvo Javier Boné, Guallar Abadía María Isabel
Hospital Universitario Miguel Servet, Zaragoza, España.
Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
An Pediatr (Engl Ed). 2020 Jun;92(6):345-350. doi: 10.1016/j.anpedi.2019.09.011. Epub 2020 Feb 29.
Food Protein-Induced Enterocolitis Syndrome (FPIES) is a gastrointestinal syndrome due to a non-IgE mediated food hypersensitivity.. The most common triggers are cow's milk and soy. Fish is one of the most frequently reported causes in Spain. The objective of this study is to describe the clinical characteristics of patients diagnosed with (FPIES) in a Paediatric Allergy Clinic.
A retrospective descriptive study was carried out by reviewing medical records of patients diagnosed with FPIES in the Paediatric Allergy Unit of the Miguel Servet Children's Hospital from the years 2007 to 2017.
A total of 135 patients were diagnosed during the study period, of whom 45% were male and 55% were female. The mean age at diagnosis was 11±1.5 months and the mean age of improvement was 2 years and 6 months±2.5 years (n=83). A personal history of atopy was observed in 31.9%. The main trigger foods were: white fish (41.4%), cow's milk (25.1%), and egg (15.5%). A conversion to IgE-mediated allergy was seen in 4.4% of patients. There was vomiting in 81.5% of the cases, with a mean of 1.75±1.1hours of latency, as well as diarrhoea in 41.5%, with a mean of 7.86±15.16hours of latency, and decline in 30.4% with a mean latency of 3.81±11.57hours.
In our series, the most frequent trigger of the FPIES was fish. It was manifested mainly by late vomiting and a tolerance was reached mostly at 2 years 6 months.
食物蛋白诱导的小肠结肠炎综合征（FPIES）是一种由非IgE介导的食物过敏引起的胃肠道综合征。最常见的诱因是牛奶和大豆。在西班牙，鱼类是最常报告的病因之一。本研究的目的是描述在一家儿科过敏诊所被诊断为FPIES的患者的临床特征。
通过回顾2007年至2017年在米格尔·塞尔维特儿童医院儿科过敏科被诊断为FPIES的患者的病历，进行了一项回顾性描述性研究。
在研究期间共诊断出135例患者，其中45%为男性，55%为女性。诊断时的平均年龄为11±1.5个月，病情改善的平均年龄为2岁6个月±2.5岁（n = 83）。31.9%的患者有特应性个人史。主要的诱发食物为：白鱼（41.4%）、牛奶（25.1%）和鸡蛋（15.5%）。4.4%的患者转变为IgE介导的过敏。81.5%的病例出现呕吐，平均潜伏期为1.75±1.1小时，41.5%的病例出现腹泻，平均潜伏期为7.86±15.16小时，30.4%的病例出现拒食，平均潜伏期为3.81±11.57小时。
在我们的系列研究中，FPIES最常见的诱因是鱼类。其主要表现为延迟呕吐，大多数患者在2岁6个月时达到耐受。
