Research Group for Genomic Epidemiology, National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark.
Foodborne Infections, Department of Bacteria, Parasites and Fungi, Statens Serum Institute, Copenhagen, Denmark.
Sci Data. 2020 Mar 3;7(1):75. doi: 10.1038/s41597-020-0417-7.
Zoonotic Salmonella causes millions of human salmonellosis infections worldwide each year. Information about the source of the bacteria guides risk managers on control and preventive strategies. Source attribution is the effort to quantify the number of sporadic human cases of a specific illness to specific sources and animal reservoirs. Source attribution methods for Salmonella have so far been based on traditional wet-lab typing methods. With the change to whole genome sequencing there is a need to develop new methods for source attribution based on sequencing data. Four European datasets collected in Denmark (DK), Germany (DE), the United Kingdom (UK) and France (FR) are presented in this descriptor. The datasets contain sequenced samples of Salmonella Typhimurium and its monophasic variants isolated from human, food, animal and the environment. The objective of the datasets was either to attribute the human salmonellosis cases to animal reservoirs or to investigate contamination of the environment by attributing the environmental isolates to different animal reservoirs.
动物源沙门氏菌每年在全球导致数百万人感染沙门氏菌病。有关细菌来源的信息可指导风险管理人员采取控制和预防策略。源归因是定量特定疾病的散发性人类病例数量到特定来源和动物宿主的过程。迄今为止,沙门氏菌的源归因方法基于传统的湿实验室分型方法。随着全基因组测序的改变,需要开发基于测序数据的新的源归因方法。本描述符介绍了在丹麦 (DK)、德国 (DE)、英国 (UK) 和法国 (FR) 收集的四个欧洲数据集。这些数据集包含了从人类、食品、动物和环境中分离出的沙门氏菌 Typhimurium 及其单相变体的测序样本。这些数据集的目的要么是将人类沙门氏菌病病例归因于动物宿主,要么是通过将环境分离物归因于不同的动物宿主来调查环境的污染情况。