氯霉素与头孢曲松治疗棉兰Putri Hijau Kesdam I/Bb医院收治儿童伤寒热的疗效对比研究
Comparative Effectiveness Study of Chloramphenicol and Ceftriaxone in the Treatment of Typhoid Fever in Children Admitted to Putri Hijau Kesdam I/Bb Hospital Medan.
作者信息
Dasopang Eva Sartika, Hasanah Fenny, Bakri Teddy Kurniawan, Isma Muktia
机构信息
Pharmacy Department, Faculty of Pharmacy, Tjut Nyak Dhien University of Medan, Medan, Indonesia.
Pharmacy Departement, Faculty of Pharmacy, Tjut Nyak Dhien University of Medan, Medan, Indonesia.
出版信息
Open Access Maced J Med Sci. 2019 Nov 14;7(22):3847-3851. doi: 10.3889/oamjms.2019.517. eCollection 2019 Nov 30.
BACKGROUND
Typhoid fever is a disease caused by Salmonella typhi bacteria, especially attacking the digestive tract. Chloramphenicol is the main drug of choice for the treatment of typhoid fever. But along with the advancement of the medical field, other medicines were developed. Ceftriaxone is an effective drug for the treatment of typhoid fever in the short term. But the price of ceftriaxone is more expensive.
AIM
The aim of this study was comparative effectiveness study of Chloramphenicol and Ceftriaxone in the treatment of typhoid fever in children admitted to Putri Hijau Kesdam I/BB Hospital Medan.
METHODS
This study was conducted cross-sectionally about the treatment of typhoid fever in children who were hospitalized at TK II PutriHijau Hospital Kesdam I/BB Medan. the patient used cloramfenikol antibiotics in 13 patients and used ceftriaxone in 17 patients. Patient age ranges from 0-19 years. Antibiotic analysis is the best effectiveness using the ACER method.
RESULTS
He results of the patient characteristics show that the children of patients who suffer from typhoid fever, the highest age is 12-16 years (50%), by gender male 60% and female 40%. Patients hospitalized using chloramfenicol averaged 6.53 days (7 days) while ceftriaxon averaged 4.17 days. The average number of direct medical costs in pediatric patients suffering from typhoid fever using cloramfenikol was 3,212,776/patient while ceftriaxon 1,967,045/patient. Cost effectiveness analysis using ACER method obtained results for cloramenicenicol at 492.002/day and ceftriaxon 471,713/day.
CONCLUSON
Ceftriaxone has a better treatment effectiveness compared to chloramphenicol in typhoid fever patients in children.
背景
伤寒热是一种由伤寒杆菌引起的疾病，主要侵袭消化道。氯霉素是治疗伤寒热的主要首选药物。但随着医学领域的发展，其他药物也被研发出来。头孢曲松是治疗伤寒热的一种短期有效药物。但头孢曲松的价格更昂贵。
目的
本研究的目的是比较氯霉素和头孢曲松在棉兰市第一军区医院绿色公主医院收治的儿童伤寒热治疗中的有效性。
方法
本研究对棉兰市第一军区医院绿色公主医院儿科二病区住院的儿童伤寒热治疗进行了横断面研究。13例患者使用氯苯尼考抗生素，17例患者使用头孢曲松。患者年龄范围为0至19岁。采用ACER方法进行抗生素分析以确定最佳有效性。
结果
患者特征结果显示，患伤寒热患者的儿童中，最高年龄为12至16岁（50%），按性别划分男性占60%，女性占40%。使用氯霉素住院的患者平均住院6.53天（7天），而使用头孢曲松的平均住院4.17天。患伤寒热的儿科患者使用氯苯尼考的平均直接医疗费用为每位患者3,212,776，而使用头孢曲松的为每位患者1,967,045。采用ACER方法进行成本效益分析，氯苯尼考的结果为每天492.002，头孢曲松为每天471,713。
结论
在儿童伤寒热患者中，头孢曲松的治疗效果比氯霉素更好。
Zotero 插件