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18名潜水员在使用氦氧混合气压缩至360米海水深度时的高压神经综合征效应。

HPNS effects among 18 divers during compression to 360 msw on heliox.

作者信息

Vaernes R J, Bergan T, Warncke M

机构信息

Norwegian Underwater Technology Centre, Ytre Laksevåg.

出版信息

Undersea Biomed Res. 1988 Jul;15(4):241-55.

PMID:3212842
Abstract

Heliox compression deeper than 16 ATA can lead to EEG changes associated with confusion and somnolence. In man the symptoms termed the high pressure neurologic syndrome (HPNS) can also include increased tremor, memory problems, dizziness, nausea, and vomiting. In a series of 3 dives at NUTEC, a compression profile developed for operational use down to 360 msw was evaluated. In each dive 6 different divers were compressed to 360 msw on heliox. Neuropsychologic and neurophysiologic testing were performed repeatedly. The HPNS testing revealed only mild effects of the compression. Only 3 divers had impairments of more than 2 SD in peripheral motor function compared to their predive average. Memory was impaired periodically in 2 divers. The same was found for perceptual speed and reasoning. Fifty percent of the divers had an increase of more than 2 SD in postural tremor, but that had minimal effect on their motor performance. Six of the 18 divers had an EEG power spectrum with both alpha band inhibition and theta increase. While the performance impairment was most marked around 240 msw, the EEG changes occurred mainly deeper than 300 msw. In only 1 of the 18 divers marked EEG changes, marked tremor increase, and marked cognitive performance impairment were observed at the same time. Although mild HPNS was observed, the divers were little impaired during the compression to 360 msw. The results confirm that using a compression profile with rates decreasing progressively with increasing depth, and with several intermediate stops, provides fit divers at depth. By using standard batteries of HPNS testing we were able to obtain evidence for the acceptability of this compression profile.

摘要

超过16个绝对大气压(ATA)的氦氧混合气高压暴露会导致脑电图变化,出现意识模糊和嗜睡症状。在人类中,这种被称为高压神经综合征(HPNS)的症状还可能包括震颤加剧、记忆问题、头晕、恶心和呕吐。在NUTEC进行的一系列3次潜水试验中,评估了一种用于360米海水深度作业的加压方案。每次潜水时,6名不同的潜水员被用氦氧混合气加压至360米海水深度。反复进行神经心理学和神经生理学测试。HPNS测试仅显示出加压的轻微影响。与潜水前的平均水平相比,只有3名潜水员的外周运动功能受损超过2个标准差。2名潜水员的记忆力定期受损。知觉速度和推理能力也有同样情况。50%的潜水员姿势性震颤增加超过2个标准差,但这对他们的运动表现影响极小。18名潜水员中有6名的脑电图功率谱出现α波频段抑制和θ波增加。虽然性能损害在约240米海水深度时最为明显,但脑电图变化主要发生在超过300米海水深度时。18名潜水员中只有1名在同一时间出现明显的脑电图变化、震颤明显增加和认知性能明显受损。虽然观察到了轻度的HPNS,但潜水员在加压至360米海水深度期间几乎没有受到损害。结果证实,采用随着深度增加速率逐渐降低且有几个中间停留阶段的加压方案,能让潜水员适应深海环境。通过使用标准的HPNS测试组合,我们能够获得该加压方案可接受性的证据。

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