Lillo R S, MacCallum M E, Pitkin R B
Diving Medicine Department, Naval Medical Research Institute, Bethesda, MD 20814-5055.
Undersea Biomed Res. 1988 Jul;15(4):283-300.
Air vs. He-O2 (20.9% O2) recompression treatment was examined in a model of severe decompression sickness (DCS) using male albino guinea pigs (Cavia porcellus, 500-600 g). Following decompression to the surface from simulated air dives at 200 or 250 fsw, both anesthetized and unanesthetized animals often exhibited responses indicative of a fatal bout of DCS (including hypotension, cardiac arrhythmia, and tachypnea). Upon recompression with air back to depth, good recovery of animals with DCS was observed. Comparison of air vs. He-O2 recompression responses of unanesthetized animals with recompression back to initial depth (200 fsw) revealed a slower recovery from tachypnea with He-O2. Recompression partially back to depth following 200-fsw air dives produced significant differences in the breathing recovery vs. recompression depth relationship between air and He-O2. Treatment effectiveness improved with increasing depth with air, but not with He-O2. These data indicate potential differences in recompression response to air vs. He-O2 when using ventilatory recovery as a measure of effectiveness in treatment of DCS in guinea pigs following air dives.
在使用雄性白化豚鼠（豚鼠，体重500 - 600克）的严重减压病（DCS）模型中，研究了空气与氦氧混合气（20.9%氧气）再压缩治疗的效果。从200或250英尺海水深度的模拟空气潜水减压至水面后，麻醉和未麻醉的动物均常表现出致命性减压病发作的反应（包括低血压、心律失常和呼吸急促）。用空气再压缩回原深度后，观察到患有减压病的动物恢复良好。对未麻醉动物从初始深度（200英尺海水深度）再压缩时空气与氦氧混合气再压缩反应进行比较，发现氦氧混合气组呼吸急促恢复较慢。200英尺海水深度空气潜水后部分再压缩回原深度，空气和氦氧混合气在呼吸恢复与再压缩深度关系上产生了显著差异。空气再压缩治疗效果随深度增加而改善，而氦氧混合气则不然。这些数据表明，在以通气恢复作为衡量豚鼠空气潜水后减压病治疗效果的指标时，空气与氦氧混合气再压缩反应存在潜在差异。
