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聚集诱导发光:材料及生物医学应用的新进展。

Aggregation-Induced Emission: Recent Advances in Materials and Biomedical Applications.

机构信息

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore.

出版信息

Angew Chem Int Ed Engl. 2020 Jun 15;59(25):9868-9886. doi: 10.1002/anie.202000845. Epub 2020 May 7.

Abstract

The concept of aggregation-induced emission (AIE) has opened new opportunities in many research fields. Motivated by the unique feature of AIE fluorogens (AIEgens), during the past decade, many AIE molecular probes and AIE nanoparticle (NP) probes have been developed for sensing, imaging and theranostic applications with excellent performance outperforming conventional fluorescent probes. This Review summarizes the latest advancement of AIE molecular probes and AIE NP probes and their emerging biomedical applications. Special focus is to reveal how the AIE probes are evolved with the development of new multifunctional AIEgens, and how new strategies have been developed to overcome the limitations of traditional AIE probes for more translational applications via fluorescence imaging, photoacoustic imaging and image-guided photodynamic/photothermal therapy. The outlook discusses the challenges and future opportunities for AIEgens to advance the biomedical field.

摘要

聚集诱导发光(AIE)的概念为许多研究领域开辟了新的机遇。受 AIE 荧光团(AIEgens)独特性质的启发,在过去十年中,已经开发出许多 AIE 分子探针和 AIE 纳米颗粒(NP)探针,用于传感、成像和治疗应用,其性能优于传统荧光探针。本综述总结了 AIE 分子探针和 AIE NP 探针的最新进展及其新兴的生物医学应用。特别关注的是揭示了 AIE 探针如何随着新型多功能 AIEgens 的发展而发展,以及如何通过荧光成像、光声成像和图像引导光动力/光热治疗克服传统 AIE 探针的局限性,开发出更多转化应用的新策略。展望部分讨论了 AIEgens 推进生物医学领域的挑战和未来机遇。

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